3810-10-4

Basic information

• Product Name: 2-AMINO-3-BENZOYLPYRIDINE
• Synonyms: 2-AMINO-3-BENZOYLPYRIDINE;(2-AMino-3-pyridinyl)phenyl-Methanone;2-AMino-3-pyridyl Phenyl Ketone
• CAS NO: 3810-10-4
• Molecular Formula: C₁₂H₁₀N₂O
• Molecular Weight: 198.22
• Product Categories: Amines;Aromatics;Heterocycles;Intermediates;Amines, Aromatics, Heterocycles, Intermediates
• Mol File: 3810-10-4.mol
• Article Data: 16

Chemical Properties

• Melting Point: 145-148 °C
• Boiling Point: 403.246 °C at 760 mmHg
• Flash Point: 197.676 °C
• Appearance: /
• Density: 1.216 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.635
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility: Dichloromethane, Methanol
• PKA: 4.79±0.36(Predicted)
• CAS DataBase Reference: 2-AMINO-3-BENZOYLPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-3-BENZOYLPYRIDINE(3810-10-4)
• EPA Substance Registry System: 2-AMINO-3-BENZOYLPYRIDINE(3810-10-4)

Safety Data

• Hazardous Substances Data: 3810-10-4(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

InChI:InChI=1/C12H10N2O/c13-12-10(7-4-8-14-12)11(15)9-5-2-1-3-6-9/h1-8H,(H2,13,14)

Upstream product

• 64362-32-9 3-benzoylpyridine-2-carboxylic acid 
• 79574-71-3 (2-fluoropyridin-3-yl)phenylmethanone 
• 109-09-1 2-chloropyridine 
• 24517-64-4 2-amino-3-pyridinecarbonitrile 
• 873-55-2 sodium benzenesulfonate 
• 98-80-6 phenylboronic acid 
• 100-58-3 phenylmagnesium bromide 
• 504-29-0 2-aminopyridine 
• 1360114-38-0 C₁₄H₁₁BrN₂O₂ 
• 6919-61-5 N-methoxy-N-methylbenzamide 
• 86847-59-8 2-(pivaloylamino)pyridine 
• 100-52-7 benzaldehyde 
• 79574-62-2 2-fluoro-3-(phenyl-1-hydroxymethyl)pyridine 
• 372-48-5 2-fluoropyridine 

Downstream Products

• 125867-44-9 5-phenyl-6,7,8,9-tetrahydrobenzo<1,8>naphthiridine 
• 28721-30-4 4-phenyl-1,2-dihydropyrido<2,3-d>-2-pyrimidinone 
• 103409-25-2 2-amino-4-phenyl-1,8-naphthyridine-3-carbonitrile 
• 103409-24-1 3-cyano-2-hydroxy-4-phenyl-1,8-naphthyridine 
• 128175-04-2 5,11-diphenyldipyrido<2,3-b:2',3'-f><1,5>diazocine 
• 130277-16-6 2-amino-3-benzylpyridine 
• 167754-45-2 N-(3-benzoylpyridin-2-yl)-2,2,2-trichloroacetamide 
• 835882-03-6 (2-amino-5-bromo-pyridin-3-yl)-phenyl-methanone 
• 103409-26-3 2-amino-4-phenyl-1,8-naphthyridine-3-carboxamide 
• 1052716-77-4 (1-Methyl-2-oxo-5-phenyl-2,3-dihydro-1H-pyrido[2,3-e][1,4]diazepin-3-yl)-carbamic acid benzyl ester 
• 1057654-48-4 [Amino-(3-benzoyl-pyridin-2-ylcarbamoyl)-methyl]-carbamic acid benzyl ester 

Relevant articles and documents

Enantioselective Intramolecular Copper-Catalyzed Borylacylation

An enantioselective copper-catalyzed intramolecular borylacylation is reported. The reaction proceeds through an initial enantioselective borylcupration of the styrene, followed by a nucleophilic attack on the tethered carbamoyl chloride. The products, chiral borylated 3,3-disubstituted oxindoles, were generated in excellent yields and enantioselectivities. The versatile carbon–boron bond provides a platform for a wide array of diversification.

COMPOUNDS

The present invention provides a compound incorporating a group of formula (I) wherein: 1 of X, Y and Z is nitrogen and the other 2 are carbon; R" is hydrogen, methyl, ethyl or propyl; and W represents hydrogen, carbon, nitrogen, oxygen or sulphur; or incorporating a salt, hydrate or solvate of a group of formula (I); as well as therapeutic uses of these compounds, in particular as inhibitors of protein kinase activity and in the treatment of inflammation, inflammatory conditions and cancer.

Palladium-catalyzed direct addition of 2-Aminobenzonitriles to sodium arylsulfinates: Synthesis of o-Aminobenzophenones

The first example of the palladium-catalyzed synthesis of o-Aminobenzophenones in moderate to excellent yields via a direct addition of sodium arylsulfinates to unprotected 2-Aminobenzonitriles was reported. A plausible mechanism for the formation of o-Aminobenzophenones involving desulfination and addition reactions was proposed. The utility of this transformation was demonstrated by its compatibility with a wide range of functional groups. Thus, the method represents a convenient and practical strategy for synthesis of o-Aminobenzophenones.