38216-72-7

Basic information

• Product Name: 1-tert-Butylpiperazine
• Synonyms: 2-Methyl-2-(piperazin-1-yl)propane;Piperazine, 1-(1,1-dimethylethyl)-;N-TERT-BUTYLPIPERAZINE;N-T-BUTYLPIPERAZINE;1-T-BUTYLPIPERAZINE;1-tert-Butylpiperazine;1-(tert-Butyl)piperazine 98+%;1-(tert-Butyl)piperazine, tech
• CAS NO: 38216-72-7
• Molecular Formula: C₈H₁₈N₂
• Molecular Weight: 142.24
• Mol File: 38216-72-7.mol
• Article Data: 7

Chemical Properties

• Melting Point: 32-35℃
• Boiling Point: 85-87℃/22mm
• Flash Point: 57.2 °C
• Appearance: Colorless to yellow/Low Melting Solid
• Density: 0.89 g/cm³
• Vapor Pressure: 0.713mmHg at 25°C
• Refractive Index: 1.457
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 9.27±0.10(Predicted)
• Sensitive: Light, Air & Moisture Sensitive
• CAS DataBase Reference: 1-tert-Butylpiperazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-tert-Butylpiperazine(38216-72-7)
• EPA Substance Registry System: 1-tert-Butylpiperazine(38216-72-7)

Safety Data

• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37/39-45
• HazardClass: 8
• Hazardous Substances Data: 38216-72-7(Hazardous Substances Data)

Usage

InChI:InChI=1/C8H18N2/c1-8(2,3)10-6-4-9-5-7-10/h9H,4-7H2,1-3H3

Upstream product

• 61014-96-8 3-(2-tert-butylamino-ethyl)-oxazolidin-2-one 
• 507-20-0 tertiary butyl chloride 
• 7542-23-6 piperazine hydrochloride 
• 61014-95-7 4-tert-butyl-piperazine-1-carboxylic acid ethyl ester 
• 40489-73-4 1-benzyl-4-(tert-butyl)piperazine 

Downstream Products

• 69478-67-7 11-(4-tert-butyl-piperazin-1-yl)-2-chloro-dibenzo[b,f][1,4]oxazepine 
• 853297-22-0 N-[4-(4-tert-butyl-piperazin-1-ylmethyl)-3-trifluoromethyl-phenyl]-2,2,2-trifluoro-acetamide 

Relevant articles and documents

Heteroaromatic acetamide derivative, preparation and applications thereof

The present invention provides a heteroaromatic acetamide derivative, a preparation and applications thereof, wherein the derivative comprises a pharmaceutically acceptable salt and/or a solvate thereof. According to the present invention, the experiment results prove that the heteroaromatic acetamide derivative can specifically bind to transient receptor potential ankyrin 1 (TRPA1) and inhibit orreduce the activity of TRPA1, and can be used for treating diseases mediated by TRPA1; and the inhibitor of the present invention further comprises a pharmaceutical composition of the compound, and amethods for preparing the compounds. The derivative has a general formula defined in the specification.

DIARYL-CYCLYLALKYL DERIVATIVES AS CALCIUM CHANNEL BLOCKERS

Methods and compounds effective in ameliorating conditions characterized by unwanted calcium channel activity, particularly unwanted N-type and/or T-type calcium channel activity are disclosed. Specifically, a series of compounds of substituted or unsubstituted N-cyclylalkyl-diphenylpropanamide derivatives as shown in formula (1).

Use of 2-Oxazolidinones As Latent Aziridine Equivalents. III. Preparation of N-Substituted Piperazines.

A number of N-aryl and N-alkyl substituted piperazines 1 were prepared from variously substituted 2-oxazolidinone derivatives 3.The method involved treatment of 3 with HBr in glacial acetic acid followed by heating the resulting ring-opened salts 5 in alcoholic solvent.The piperazines 1a-1q were isolated by crystallization in yields ranging from 23-91percent.