38289-28-0Relevant articles and documents
Improved synthesis of trans-4-alkylcyclohexane carboxylic acids
Bazurin, Alexey A.,Krasnikov, Sergey V.,Obuchova, Tatiana A.,Danilova, Angelina S.,Balakin, Konstantin V.
, p. 6669 - 6672 (2007/10/03)
Several stereomerically pure amino acid derivatives containing the N-terminal trans-4-alkylcyclohexanoyl fragment were obtained. Hydrogenation of 4-alkylbenzoic acids in the presence of a special Ru-Ni/C catalytic system and isomerization of the resulting mixture of trans- and cis-isomers of 4-alkylcyclohexanecarboxylic acids were used as the key steps. The stereomeric configuration of all compounds was confirmed by 1H NMR spectroscopy. The compounds obtained possess a broad biological activity potential and are useful intermediates in the synthesis of stereomerically pure modified peptides.
Synthesis of Mesogenic Compounds, Catalyzed by Metal Complexes. II. A New Method of Synthesis of 4,4'-Dialkylbiphenyls
Bumagin, N. A.,Luzikova, E. V.,Beletskaya, I. P.
, p. 1487 - 1491 (2007/10/03)
A new method for the synthesis of 4,4'-dialkylbiphenyls containing both n-alkyl- and 4-trans-n-alkylcyclohexyl substituents, based on highly selective reactions of monoalkylation and monoacylation of 1,4-dibromobenzene in the presence of palladium complexes is developed.
ISOMERIZATION UNDER THE INFLUENCE OF p-TOLUENESULFONIC ACID.
Kovshev,Karamysheva,Torgova,Geivandova,Roitman
, p. 1069 - 1070 (2007/10/02)
The authors have investigated the influence of a mild acid isomerization catalyst, p-toluenesulfonic acid (TSA), on 4-butyl- (Ia) and 4-hexyl- (Ib) cyclohexanecarboxylic acids and their methyl esters (IIa, IIb). It is found that p-toluenesulfonic acid is an effective catalyst of cis-trans isomerization of 4-alkylcyclohexanecarboxylic acids and their esters; removal of water from the reaction medium raises the isomerization rate. Esters of alkylcyclohexanecarboxylic acids are isomerized at higher rates than the acids themselves. A probable mechanism of the acid-catalyzed isomerization reaction is proposed.