383129-21-3

Basic information

• Product Name: 2-(3-CHLORO-PHENYL)-AZEPANE
• Synonyms: 2-(3-Chlorophenyl)hexahydro-1H-azepine
• CAS NO: 383129-21-3
• Molecular Formula: C12H16ClN
• Molecular Weight: 209.72
• Mol File: 383129-21-3.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Density: 1.068
• CAS DataBase Reference: 2-(3-CHLORO-PHENYL)-AZEPANE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-CHLORO-PHENYL)-AZEPANE(383129-21-3)
• EPA Substance Registry System: 2-(3-CHLORO-PHENYL)-AZEPANE(383129-21-3)

Safety Data

• Hazardous Substances Data: 383129-21-3(Hazardous Substances Data)

Usage

General Description

2-(3-chloro-phenyl)-azepane is a chemical compound that belongs to the class of azepanes, which are seven-membered heterocyclic compounds containing a nitrogen atom. It is also known as 3-(2-azepanyl)chlorophenyl. 2-(3-CHLORO-PHENYL)-AZEPANE is a chlorinated derivative of azepane and has a molecular formula of C11H15ClN. It is commonly used in the pharmaceutical industry as a building block for the synthesis of various drugs and biologically active compounds. The chloro-phenyl group in the molecule adds certain properties and functionalities to the compound, making it useful in the development of new drugs with potential therapeutic applications.

Relevant articles and documents

Discovery, synthesis and exploration of N-benzylsulfonyl-2-phenylazepanes as inhibitors of Bim expression in a mouse embryonic fibroblast model

Chronic activation of beta-adrenergic receptors by the sympathetic nervous system results in the apoptosis of cardiomyocytes. Due to the inability of cardiomyocytes to regenerate, this can result in heart failure. Upregulation of the pro-apoptotic protein Bim has been implicated as the cause of cardiomyocyte apoptosis. Beta blockers are the frontline drug used to negate this apoptotic pathway, as no direct inhibitors of Bim expression currently exist. Unfortunately, treatment of heart failure using beta blockers is not optimal. Therefore, direct inhibition of Bim expression is an attractive strategy to provide protection against stress-induced apoptosis of cardiomyocytes. Herein we explore a class of N-benzylsulfonyl-2-phenylazepanes to obtain anti-apoptotic compounds capable of reducing Bim expression levels to 7% of the control at 10 μM in cardiomyocytes under conditions of chronic beta-adrenergic receptor activation with little inhibitory effect upon protein kinase A activity and minimal toxicity.