38362-89-9

Basic information

• Product Name: Benzene, 1-methyl-2-(nitromethyl)-
• Synonyms: o-Methylphenyl-nitromethan;1-methyl-2-(2-nitroethyl)benzene;Benzene,1-methyl-2-(nitromethyl);(2-methylphenyl)nitromethane;1-Methyl-2-nitromethyl-benzol;1-methyl-2-(nitro-methyl)-benzene
• CAS NO: 38362-89-9
• Molecular Formula: C8H9NO2
• Molecular Weight: 151.165
• Mol File: 38362-89-9.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 249.5±9.0 °C(Predicted)
• Density: 1.121±0.06 g/cm3(Predicted)
• CAS DataBase Reference: Benzene, 1-methyl-2-(nitromethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-methyl-2-(nitromethyl)-(38362-89-9)
• EPA Substance Registry System: Benzene, 1-methyl-2-(nitromethyl)-(38362-89-9)

Safety Data

• Hazardous Substances Data: 38362-89-9(Hazardous Substances Data)

Upstream product

• 552-45-4 1-chloromethyl-2-methylbenzene 
• 75-52-5 nitromethane 
• 95-46-5 2-methylphenyl bromide 
• 89-92-9 2-methylbenzyl bromide 
• 95-47-6 o-xylene 
• 74737-96-5 1-methyl-2-<2-nitro-2-(phenylsulfonyl)-ethyl>benzene 
• 22364-68-7 2-tolylmethylnitrile 

Downstream Products

• 14683-79-5 (E)-2-methylbenzaldehyde oxime 
• 1352191-79-7 (5-methyl-3-o-tolyl-4,5-dihydroisoxazole-5-yl)methanol 

Relevant articles and documents

Integrating Hydrogen Production and Transfer Hydrogenation with Selenite Promoted Electrooxidation of α-Nitrotoluenes to E-Nitroethenes

Developing an electrochemical carbon-added reaction with accelerated kinetics to replace the low-value and sluggish oxygen evolution reaction (OER) is markedly significant to pure hydrogen production. Regulating the critical steps to precisely design electrode materials to selectively synthesize targeted compounds is highly desirable. Here, inspired by the surfaced adsorbed SeOx2? promoting OER, NiSe is demonstrated to be an efficient anode enabling α-nitrotoluene electrooxidation to E-nitroethene with up to 99 % E selectivity, 89 % Faradaic efficiency, and the reaction rate of 0.25 mmol cm?2 h?1 via inhibiting side reactions for energy-saving hydrogen generation. The high performance can be associated with its in situ formed NiOOH surface layer and absorbed SeOx2? via Se leaching-oxidation during electrooxidation, and the preferential adsorption of two -NO2 groups of intermediate on NiOOH. A self-coupling of α-carbon radicals and subsequent elimination of a nitrite molecule pathway is proposed. Wide substrate scope, scale-up synthesis of E-nitroethene, and paired productions of E-nitroethene and hydrogen or N-protected aminoarenes over a bifunctional NiSe electrode highlight the promising potential. Gold also displays a similar promoting effect for α-nitrotoluene transformation like SeOx2?, rationalizing the strategy of designing materials to suppress side reactions.

Catalytic Asymmetric Cycloadditions of Silyl Nitronates Bearing α-Aryl Group

1,3-Dipolar cycloadditions of 2-alkylacroleins or atropaldehyde with triisopropylsilyl nitronates bearing an α-aryl group produced 3-aryl-2-isoxazolines having a chiral quaternary center in up to 94% ee and up to 88% yield with the aid of Corey’s oxazaborolidine catalyst. Specifically, the TIPS nitronate with an α-(p-methoxyphenyl) group gave mainly the 2-isoxazolines having an all-carbon quaternary center.

Palladium-catalyzed nitromethylation of aryl halides: An orthogonal formylation equivalent

An efficient cross-coupling reaction of aryl halides and nitromethane was developed with the use of parallel microscale experimentation. The arylnitromethane products are precursors for numerous useful synthetic products. An efficient method for their direct conversion to the corresponding oximes and aldehydes in a one-pot operation has been discovered. The process exploits inexpensive nitromethane as a carbonyl equivalent, providing a mild and convenient formylation method that is compatible with many functional groups.