38379-21-4

Basic information

• Product Name: Benzenemethanamine, 2-ethynyl- (9CI)
• Synonyms: Benzenemethanamine, 2-ethynyl- (9CI);(2-Ethynylphenyl)methanamine
• CAS NO: 38379-21-4
• Molecular Formula: C₉H₉N
• Molecular Weight: 131.17446
• Mol File: 38379-21-4.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Benzenemethanamine, 2-ethynyl- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenemethanamine, 2-ethynyl- (9CI)(38379-21-4)
• EPA Substance Registry System: Benzenemethanamine, 2-ethynyl- (9CI)(38379-21-4)

Safety Data

• Hazardous Substances Data: 38379-21-4(Hazardous Substances Data)

Usage

Uses

2-Ethynylbenzylamine is useful building block in the synthesis of dyes.

Upstream product

• 97308-62-8 1-(2-cyanophenyl)-2-(trimethylsilyl)acetylene 
• 40888-26-4 2-ethynylbenzonitrile 
• 4387-36-4 2-iodobenzonitrile 

Relevant articles and documents

Synthesis of Pyrrolo[1,2- b]isoquinolines via Gold(I)-Catalyzed Cyclization/Enyne Cycloisomerization/1,2-Migration Cascade

A gold(I)-catalyzed cascade transformation of N-alkynic 2-ynamides for the rapid and efficient synthesis of the indolizidine scaffold is developed. Through a sequential nucleophilic cyclization/enyne cycloisomerization/1,2-migration process, diverse pyrrolo[1,2-b]isoquinolines are obtained under mild conditions in a regiospecific and convergent manner. Various alkyl and aryl migrating groups are tolerated in this process. The electronic effect of the migrating group is comprehensively investigated. The study of the mechanism indicates that the pathway involving a gold carbenoid species is the main pathway and that the 1,2-migration of alkyl and aryl groups to the gold carbenoid occurs in an intramolecular fashion. This cascade reaction is also employed as the key step for the synthesis of a decumbenine B analogue.

Synthesis of N-Heteroaromatic Compounds through Cyclocarbonylative Sonogashira Reactions

A protocol based on cyclocarbonylative Sonogashira reactions has been developed for the synthesis of nitrogen-containing heterocycles. The process is carried out under CO pressure, in the presence of a small amount of PdCl2(PPh3)sub

Ruthenium-catalyzed cycloisomerization of aromatic homo- and bis-homopropargylic amines/amides: Formation of indoles, dihydroisoquinolines and dihydroquinolines

Ruthenium-catalyzed cycloisomerizations of aromatic homo- and bis-homopropargylic amines/amides efficiently afford indoles, dihydroisoquinolines and dihydroquinolines. These processes were regioselective (5- and 6-endo cyclizations) on using key Ru vinylidene intermediates. The presence of an amine/ammonium base-acid pair increased the rate of cyclization and facilitated the catalytic turnover. Copyright