38412-47-4

Basic information

• Product Name: 2,5－Dimethyl－7－hydroxy chromone
• Synonyms: 2,5－Dimethyl－7－hydroxy chromone;7-Hydroxy-2,5-dimethyl-4H-1-benzopyran-4-one;7-Hydroxy-2,5-dimethylchromone;Altechromone A
• CAS NO: 38412-47-4
• Molecular Formula: C₁₁H₁₀O₃
• Molecular Weight: 190.2
• Mol File: 38412-47-4.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2,5－Dimethyl－7－hydroxy chromone(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5－Dimethyl－7－hydroxy chromone(38412-47-4)
• EPA Substance Registry System: 2,5－Dimethyl－7－hydroxy chromone(38412-47-4)

Safety Data

• Hazardous Substances Data: 38412-47-4(Hazardous Substances Data)

Usage

General Description

2,5－Dimethyl－7－hydroxy chromone is a chemical compound with the molecular formula C11H10O3. It is a natural product found in certain plants and has been identified as a bioactive compound with potential medicinal properties. 2,5－Dimethyl－7－hydroxy chromone has been studied for its antioxidant and anti-inflammatory properties, which may make it useful in the treatment of various health conditions. Additionally, research has shown that this compound has anti-cancer and anti-microbial activities, further highlighting its potential as a therapeutic agent. Overall, 2,5－Dimethyl－7－hydroxy chromone is a promising compound with diverse potential applications in medicine and healthcare.

Upstream product

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Relevant articles and documents

Inhibition of BACE1 and amyloid β aggregation by polyketide from Streptomyces sp.

Alzheimer's disease (AD) causes cognitive impairment in the elderly and is a severe problem worldwide. One of the major reasons for the pathogenesis of AD is thought to be due to the accumulation of amyloid beta (Aβ) peptides that result in neuronal cell death in the brain. In this study, bioassay-guided fractionation was performed to develop seed compounds for anti-AD drugs that can act as dual inhibitors of BACE1 and Aβ aggregation from secondary metabolites produced by Streptomyces sp. To improve the solubility, the crude extracts were methylated with trimethylsilyl (TMS) diazomethane and then purified to yield polyketides 1–5, including the new compound 1. We synthesized the compounds 6 and 7 (original compounds 2 and 3, respectively), and their activities were evaluated. KS-619-1, the demethylated form of 4 and 5, was isolated and evaluated for its inhibitory activity. The IC50 values for BACE1 and Aβ aggregation were found to be 0.48 and 1.1?μM, respectively, indicating that KS-619-1 could be a lead compound for the development of therapeutic agents for AD.

Anti-AIDS agents 89. Identification of DCX derivatives as anti-HIV and chemosensitizing dual function agents to overcome P-gp-mediated drug resistance for AIDS therapy

In this study, 19 dicamphanoyl-dihydropyranochromone (DCP) and dicamphanoyl-dihydropyranoxanthone (DCX) derivatives, previously discovered as novel anti-HIV agents, were evaluated for their potential to reverse multi-drug resistance (MDR) in a cancer cell line over-expressing P-glycoprotein (P-gp). Seven compounds fully reversed resistance to vincristine (VCR) at 4 μM, a 20-fold enhancement compared to the first generation chemosensitizer, verapamil (4 μM). The mechanism of action of DCPs and DCXs was also resolved, since the most active compounds (3, 4, and 7) significantly increased intracellular drug accumulation due, in part, to inhibiting the P-gp mediated drug efflux from cells. We conclude that DCPs (3 and 4) and DCXs (7, 11, and 17) can exhibit polypharmacologic behavior by acting as dual inhibitors of HIV replication and chemoresistance mediated by P-gp. As such, they may be useful in combination therapy to overcome P-gp-associated drug resistance for AIDS treatment.

SYNTHESIS OF NATURALLY OCCURRING 2,5-DIALKYLCHROMONES. PART 1. SYNTHESIS OF ALOESONE AND ALOESOL

A number of 2-alkyl-7-alkoxy ( or hydroxy)-5-methyl-chromones, including naturally occurring aloesone and aloesol, were synthesized starting from ethyl orsellinate via β-keto-sulfoxides as intermediates.