3854-52-2

Basic information

• Product Name: 1-Butene, 2-(bromomethyl)-3,3-dimethyl-
• Synonyms: 1-Butene, 2-(bromomethyl)-3,3-dimethyl-
• CAS NO: 3854-52-2
• Molecular Formula: C₇H₁₃Br
• Molecular Weight: 177
• Mol File: 3854-52-2.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-Butene, 2-(bromomethyl)-3,3-dimethyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Butene, 2-(bromomethyl)-3,3-dimethyl-(3854-52-2)
• EPA Substance Registry System: 1-Butene, 2-(bromomethyl)-3,3-dimethyl-(3854-52-2)

Safety Data

• Hazardous Substances Data: 3854-52-2(Hazardous Substances Data)

Upstream product

• 594-56-9 2,2,3-trimethylbut-1-ene 
• 594-83-2 2,3,3-trimethyl-2-butanol 
• 69060-18-0 3,3-dimethyl-2-methylenebutanal 
• 39497-64-8 3,3-dimethyl-2-methylenebutan-1-ol 
• 2987-16-8 3,3-dimethylbutyrylaldehyde 
• 75-97-8 3,3-dimethyl-butan-2-one 

Downstream Products

• 3854-53-3 2,2-Dimethyl-3-benzyl-buten-⁽³⁾ 
• 847256-49-9 4,4-dimethyl-1-(2-nitrophenoxy)-3-pentanone 
• 847256-42-2 2-(3-tert-butyl-3-butenyloxy)-1-nitrobenzene 
• 1421639-44-2 N-allyl-2-bromo-N-(3,3-dimethyl-2-methylenebutyl)-4,5-dimethoxybenzenesulfonamide 
• 1421639-46-4 1-(2-bromophenylsulfonyl)-3-tert-butyl-2,5-dihydro-1H-pyrrole 
• 1421639-41-9 N-allyl-2-bromo-N-(3,3-dimethyl-2-methylenebutyl)benzenesulfonamide 
• 1601490-25-8 (S)-2-((2R,3S)-3-amino-2-hydroxy-4-phenylbutyl)-4-(tert-butyl)-7-fluoro-2,3,4,5-tetrahydrobenzo[1,2-f]thiazepine 1,1-dioxide 
• 1601490-30-5 (R)-2-((2R,3S)-3-amino-2-hydroxy-4-phenylbutyl)-4-(tert-butyl)-7-fluoro-2,3,4,5-tetrahydrobenzo[1,2-f]thiazepine 1,1-dioxide 
• 1601490-33-8 (S)-tetrahydrofuran-3-yl ((2S,3R)-4-((R)-4-(tert-butyl)-7-fluoro-1,1-dioxido-4,5-dihydrobenzo[1,2-f]thiazepin-2(3H)-yl)-3-hydroxy-1-phenylbutan-2-yl)carbamate 
• 1601490-37-2 (S)-tetrahydrofuran-3-yl ((2S,3R)-4-((S)-4-(tert-butyl)-7-fluoro-1,1-dioxido-4,5-dihydrobenzo[1,2-f]thiazepin-2(3H)-yl)-3-hydroxy-1-phenylbutan-2-yl)carbamate 
• 1601490-10-1 2-bromo-N-(3,3-dimethyl-2-methylenebutyl)-4-fluorobenzenesulfonamide 
• 92035-65-9 β-tert.-Butylallyl-phenylether 
• 100794-18-1 2,2-Dimethyl-3-methylen-5-phenyl-pentan 

Relevant articles and documents

Rhodium(I)-Catalyzed Enantioselective Cyclization of Enynes through Site-Selective C(sp 3)-H Bond Activation Triggered by Formation of Rhodacycle

Rhodium(I)-catalyzed enantioselective cyclization of enynes through C(sp 3)-H bond activation was investigated. It was found that the cyclization of enynes having a tert -butyl moiety on the alkene afforded a spirocyclic compound (up to 92% ee), while the cyclization of enynes having an isopropyl or an ethyl group on the alkene gave a cyclic diene (up to 98% ee). Furthermore, an intermolecular competition reaction using a deuterium-labeled substrate revealed that C(sp 3)-H bond activation was one of the key steps, having a high energy barrier, in this cyclization.

Pd-Catalyzed Asymmetric Acyl-Carbamoylation of an Alkene to Construct an α-Quaternary Chiral Cycloketone

Herein, we report the palladium-catalyzed asymmetric acyl-carbamoylation of an alkene by employing thioesters as the acyl electrophiles and t-BuNC as the carbamoyl reagent, affording an α-quaternary chiral cycloketone in synthetically useful yields with excellent enantioselectivity. The reaction proceeded via asymmetric 1,2-migratory insertions of acyl-Pd into alkenes and subsequent migratory insertion of isocyanides into C(sp3)-PdII. The product could be diversified to some valuable skeletons with retention of enantiopurity, demonstrating the synthetic utility of this protocol.

Organic base-catalysed solvent-tuned chemoselective carbotrifluoromethylation and oxytrifluoromethylation of unactivated alkenes

An unprecedented and efficient organic base-catalysed highly chemoselective carbo- and oxytrifluoromethylation of unactivated alkenes with Togni's reagent was developed. The switchable chemoselectivity was tuned by simply changing the organic base catalyst and solvent. Mechanistic studies indicated that a radical cyclization pathway for carbotrifluoromethylation in DMSO and a carbocation pathway for oxytrifluoromethylation in DCE were probably involved.