387353-71-1

Basic information

• Product Name: Aliskiren inter-7
• Synonyms: (2S,4E,7R)-7-[[4-Methoxy-3-(3-methoxypropoxy)phenyl]methyl]-8-methyl-2-(1-methylethyl)-4-nonenoic acid methyl ester;Aliskiren inter-7
• CAS NO: 387353-71-1
• Molecular Formula: C₂₆H₄₂O₅
• Molecular Weight: 434.61
• Mol File: 387353-71-1.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 501.7 °C at 760 mmHg
• Flash Point: 210 °C
• Appearance: /
• Density: 0.989
• Refractive Index: 1.488
• CAS DataBase Reference: Aliskiren inter-7(CAS DataBase Reference)
• NIST Chemistry Reference: Aliskiren inter-7(387353-71-1)
• EPA Substance Registry System: Aliskiren inter-7(387353-71-1)

Safety Data

• Hazardous Substances Data: 387353-71-1(Hazardous Substances Data)

Usage

General Description

Aliskiren inter-7 is a chemical compound that is used to treat high blood pressure. It belongs to the class of medications known as direct renin inhibitors, which work by blocking the effects of renin, an enzyme that helps to regulate blood pressure. By inhibiting renin, aliskiren inter-7 helps to relax and dilate blood vessels, making it easier for the heart to pump blood and lowering blood pressure. It is often prescribed in combination with other antihypertensive drugs to achieve better control of blood pressure. Aliskiren inter-7 is available in tablet form and is typically taken once a day. It is important to follow the dosage and usage instructions provided by a healthcare professional when taking this medication.

InChI:InChI=1/C26H42O5/c1-19(2)22(11-8-9-12-23(20(3)4)26(27)30-7)17-21-13-14-24(29-6)25(18-21)31-16-10-15-28-5/h8-9,13-14,18-20,22-23H,10-12,15-17H2,1-7H3/b9-8+/t22-,23+/m1/s1

Upstream product

• 1350705-32-6 (4R)-3-(2S)-(2-(hydroxy(4-methoxy-3-(3-methoxypropoxy)phenyl)methyl)-3-methylbutanoyl)-4-phenyloxazolidin-2-one 
• 1350705-33-7 (S,E)-5-chloro-2-isopropyl pent-4-enoic acid phenyl ethanamine 
• 1350705-31-5 (R)-3-((R)-2-(4-methoxy-3-(3-methoxypropoxy)benzyl)-3-methylbutanoyl)-4-phenyloxazolidin-2-one 
• 172900-75-3 4-methoxy-3-(3-methoxypropoxy)benzaldehyde 
• 172900-74-2 [4-methoxy-3-(3-methoxypropoxy)-phenyl]methanol 
• 172900-73-1 4-(bromomethyl)-1-methoxy-2-(3-methoxypropoxy)-benzene 
• 172900-71-9 (R)-3-[4-methoxy-3-(3-methoxypropoxy)phenyl]-2-(1-methylethyl)propanoic acid 
• 503-74-2 3-methylbutyric acid 
• 387353-77-7 methyl (S)-(4E)-5-chloro-2-isopropyl-4-pentenoate 
• 324763-39-5 (R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane 
• 172900-70-8 (R)-2-[4-methoxy-3-(3-methoxypropoxy)benzyl]-3-methylbutanol 

Downstream Products

• 1350705-30-4 (2S,7R,E)-2-isopropyl-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)-8-methyl non-4-enoic acid tert-butylamine 
• 393108-57-1 (3S,5S)-5-{(1R,3S)-1-bromo-3-{[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl}-4-methylpentyl}-dihydro-3-(1-methylethyl)furan-2(3H)-one 
• 173334-57-1 (2S,4S,5S,7S)-5-Amino-4-hydroxy-2-isopropyl-7-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-8-methyl-nonanoic acid (2-carbamoyl-2-methyl-propyl)-amide 
• 324763-47-5 (2S,4S,5S,7S)-N-(3-amino-2,2-dimethyl-3-oxopropyl)-5-azido-4-hydroxy-2-isopropyl-7-(4-methoxy-3-(methoxypropoxy)benzyl)-8-methylnonanamide 
• 325154-26-5 (2S,7R,E)-2-isopropyl-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)-N,N,8-trimethylnon-4-enamide 
• 325740-70-3 (3S,5S)-5-((1S,3S)-1-azido-3-(4-methoxy-3-(3-methoxypropoxy)benzyl)-4-methylpentyl)-3-isopropyldihydrofuran-2(3H)-one 

Relevant articles and documents

PROCESS FOR THE PREPARATION OF (2S,4S,5S,7S)-N-(2-CARBAMYL-2- METHYLPROPYL)-5-AMINO-4-HYDROXY-2,7-DIISOPROPYL-8-[4-METHOXY-3-(3- METHOXYPROPOXY)PHENYL]-OCTANAMIDE HEMIFUMARATE AND ITS INTERMEDIATES THEREOF

The present invention relates to a process for the preparation of (2S,4S,5S,7S)-N-(2- Carbamoyl-2-methylpropyl)-5-amino-4-hydroxy-2,7-diisopropyl-8-[4-methoxy-3-(3-methoxy propoxy )phenyl]-octanamide compound of formula- 1 and its pharmaceutically acceptable salts thereof. Further, relates to the processes for the preparation of (R)-4-(2-(halomethyl)-3- methylbutyl)-l-methoxy-2-(3-methoxypropoxy) benzene and (R)-2-(4-methoxy-3-(3-methoxy propoxy) benzyl)-3-methyIbutan-l-ol useful intermediates in the synthesis of compound of formula- 1.