38786-78-6

Basic information

• Product Name: Tetrahydro-2H-pyran-2-acetic acid ethyl ester
• Synonyms: Tetrahydro-2H-pyran-2-acetic acid ethyl ester
• CAS NO: 38786-78-6
• Molecular Formula: C₉H₁₆O₃
• Molecular Weight: 0
• Mol File: 38786-78-6.mol
• Article Data: 11

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Tetrahydro-2H-pyran-2-acetic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Tetrahydro-2H-pyran-2-acetic acid ethyl ester(38786-78-6)
• EPA Substance Registry System: Tetrahydro-2H-pyran-2-acetic acid ethyl ester(38786-78-6)

Safety Data

• Hazardous Substances Data: 38786-78-6(Hazardous Substances Data)

Upstream product

• 2761-33-3 2-acetoxytetrahydropyran 
• 105-36-2 ethyl bromoacetate 
• 142-68-7 TETRAHYDROPYRANE 
• 623-73-4 diazoacetic acid ethyl ester 
• 96251-91-1 ethyl cis/trans-7-hydroxy-2-heptenoate 
• 694-54-2 tetrahydro-2H-2-pyranol 
• 181273-30-3 (E)-7-(Tetrahydro-pyran-2-yloxy)-hept-2-enoic acid ethyl ester 
• 148760-91-2 ethyl (E)-7-acetyloxy-2-heptenoate 
• 542-28-9 3,4,5,6-tetrahydro-2H-pyran-2-one 
• 42201-84-3 1-ethoxy-1-(tert-butyldimethylsilyloxy)ethene 

Downstream Products

• 1312019-06-9 1-(1-benzenesulfonyl-1H-pyrrolo[2,3-b]pyridin-2-yl)-2-(tetrahydro-pyran-2-yl)-ethanone 
• 1312019-10-5 1-benzenesulfonyl-2-[1-(4-methanesulfonyl-phenyl)-2-(tetrahydro-pyran-2-yl)-vinyl]-1H-pyrrolo[2,3-b]pyridine 
• 1312019-11-6 2-[1-(4-methanesulfonyl-phenyl)-2-(tetrahydro-pyran-2-yl)-vinyl]-1H-pyrrolo[2,3-b]pyridine 
• 1312019-08-1 1-(1-benzenesulfonyl-1H-pyrrolo[2,3-b]pyridin-2-yl)-2-(tetrahydro-pyran-2(S)-yl)-ethanone 
• 1312019-07-0 1-(1-benzenesulfonyl-1H-pyrrolo[2,3-b]pyridin-2-yl)-2-(tetrahydro-pyran-2(R)-yl)-ethanone 
• 1312019-09-2 toluene-4-sulfonic acid 1-(1-benzenesulfonyl-1H-pyrrolo[2,3-b]pyridin-2-yl)-2-(tetrahydro-pyran-yl)-vinyl ester 
• 1312016-92-4 2-[1(R)-(4-methanesulfonyl-phenyl)-2-(tetrahydro-pyran-2(S)-yl)-ethyl-]-1H-pyrrolo[2,3-b]pyridine 
• 1312021-17-2 2-[1(S)-(4-methanesulfonyl-phenyl)-2-(tetrahydro-pyran-2(S)-yl)-ethyl-]-1H-pyrrolo[2,3-b]pyridine 
• 1312019-05-8 1-(1-benzenesulfonyl-1H-pyrrolo[2,3-b]pyridin-2-yl)-2-(tetrahydro-pyran-2-yl)-ethanol 
• 86266-57-1 2-(tetrahydropyran-2-yl)acetaldehyde 
• 860010-76-0 1-tetrahydro-2H-2-pyranylmethyl allyl-2-benzyloxy acetate 
• 38786-79-7 2-(tetrahydropyran-2-yl)ethanol 

Relevant articles and documents

TBAF-catalyzed cyclization of 6-hydroxyhex-2-ynoates and 7-hydroxyhept-2-ynoates

Tetrabutyl ammonium fluoride (TBAF) was found to be capable of catalyzing the intramolecular hydroalkoxylation of 6-hydroxyhex-2-ynoates and 7-hydroxyhept-2-ynoates. The reaction could be used to prepare 2,5-substituted THF rings and 2,6-substituted THP rings.

A novel synthesis of the north west portion of Lasonolide A - An anticancer macrolide using Claisen rearrangement

A simplified analogue of Lasonolide A (C23-C35 side chain) was synthesized using Fujisawa's stereoselective variant of the Ireland Claisen ester rearrangement.

Intermolecular copper-catalyzed carbon-hydrogen bond activation via carbene insertion

A series of catalysts of general formula TpXCu (TpX = homoscorpionate ligand) promote the insertion of :CHCO2Et (ethyl diazoacetate as the carbene source) into the C-H bonds of cycloalkanes and cyclic ethers in moderate to high yield. A correlation between the steric hindrance of these catalysts and the yield of the transformation has been observed. Copyright