38875-47-7

Basic information

• Product Name: 4-(1-phenylethyl)-o-cresol
• Synonyms: 4-(1-phenylethyl)-o-cresol;2-Methyl-4-(α-methylbenzyl)phenol
• CAS NO: 38875-47-7
• Molecular Formula: C₁₅H₁₆O
• Molecular Weight: 212.28694
• EINECS: 254-171-3
• Mol File: 38875-47-7.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 328.9 °C at 760 mmHg
• Flash Point: 155.3 °C
• Appearance: /
• Density: 1.057 g/cm³
• Vapor Pressure: 9.58E-05mmHg at 25°C
• Refractive Index: 1.58
• CAS DataBase Reference: 4-(1-phenylethyl)-o-cresol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(1-phenylethyl)-o-cresol(38875-47-7)
• EPA Substance Registry System: 4-(1-phenylethyl)-o-cresol(38875-47-7)

Safety Data

• Hazardous Substances Data: 38875-47-7(Hazardous Substances Data)

Usage

General Description

4-(1-phenylethyl)-o-cresol, also known as 4-phenylethyl-o-cresol, is a chemical compound with the molecular formula C14H16O. It is a type of phenolic compound that is commonly used in the cosmetic and personal care industry due to its antibacterial and fragrance properties. This chemical is often added to products such as deodorants, soaps, and lotions as a preservative and to impart a pleasant scent. In addition, 4-(1-phenylethyl)-o-cresol has been found to have antimicrobial and antioxidant properties, making it a versatile ingredient in various consumer products. However, there is some concern about its potential harmful effects on human health and the environment, and further research is needed to fully understand its impact.

InChI:InChI=1/C15H16O/c1-11-10-14(8-9-15(11)16)12(2)13-6-4-3-5-7-13/h3-10,12,16H,1-2H3

Upstream product

• 100-42-5 styrene 
• 95-48-7 ortho-cresol 
• 672-65-1 (1-chloroethyl)benzene 
• 98-85-1 1-Phenylethanol 

Downstream Products

• 32341-91-6 1-methyl-3-(1-phenylethyl)benzene 

Relevant articles and documents

THE FIRST APPLICATION OF ANION-CATALYZED PHASE-TRANSFER CATALYSIS TO FRIEDEL-CRAFTS ALKYLATION

Friedel-Crafts alkylation proceeded by catalysis of tetrakisborate (TFPB) in a dichloromethane-aqueous sulfuric acid two-phase system.Kinetic evidence indicated that oxonium-TFPB ion-pair in the organic phase was operative as a catalyst.

Phosphorous acid-catalyzed alkylation of phenols with alkenes

A H3PO3-catalyzed alkylation of phenols with alkenes is achieved in a facile, efficient, and selective manner. The reaction shows a unique selectivity, i.e., excellent regioselectivity, thorough suppression of overalkylation, without alkylation of a simple phenyl ring, and can selectively provide ortho-, meta-, or para-alkylated phenol derivatives in good to excellent yields. This feature along with mild reaction conditions, sensitive functional group tolerance, and scale-up synthesis and late modification of phenolic bioactive compounds make it an ideal and practical alternative for the modification of phenols.

Room Temperature Catalyst System for the Hydroarylation of Olefins

A simple protocol for the hydroarylation of olefins to yield diarylmethine products is described. A Friedel-Crafts-type synthetic strategy allows direct access to biorelevant products in high atom efficiency. A combination of substoichiometric amounts of TMSCl and ZnBr2 promotes a rapid hydroarylation process at ambient temperature. The method is high yielding and is amenable to scale-up protocols.