38934-69-9

Basic information

• Product Name: Methyl-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxylate
• Synonyms: METHYL 1-B-D-RIBOFURANOSYL-1H-1,2,4-TRIAZOLE-3-CARBOXYLATE;NSC360639;1-beta-D-Ribofuranose-1H-1,2,4-triazole-3-methylcarbonate;1-D-Furanribosyl-1,2,4-triazole-3-carboxylic acid methyl ester;Methyl 1-D-ribofuranosyl-1H-1,2,4-triazole-3-carboxylate;1-β-D-Ribofuranosyl-1,2,4-triazole-3-carboxylic Acid Methyl Ester (Ribavirin;1-b-D-Ribofuranosyl-1,2,4-triazole-3-carboxylic acid methyl ester;1-β-D-Ribofuranosyl-1,2,4-triazole-3-carboxylic Acid Methyl Ester (Ribavirin IMpurity H)
• CAS NO: 38934-69-9
• Molecular Formula: C₉H₁₃N₃O₆
• Molecular Weight: 259.216
• Product Categories: Bases & Related Reagents;Carbohydrates & Derivatives;Impurities;Intermediates & Fine Chemicals;Nucleotides;Pharmaceuticals
• Mol File: 38934-69-9.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 561.4 °C at 760 mmHg
• Flash Point: 293.3 °C
• Appearance: /
• Density: 1.82g/cm³
• Vapor Pressure: 1.94E-13mmHg at 25°C
• Refractive Index: 1.701
• Storage Temp.: Refrigerator, Under Inert Atmosphere
• Solubility: DMSO (Slightly), Methanol (Slightly)
• CAS DataBase Reference: Methyl-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxylate(38934-69-9)
• EPA Substance Registry System: Methyl-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxylate(38934-69-9)

Safety Data

• Hazardous Substances Data: 38934-69-9(Hazardous Substances Data)

Usage

Chemical Properties

White Low Melting Solid

Uses

Different sources of media describe the Uses of 38934-69-9 differently. You can refer to the following data:
1. Ribavirin impurity H.
2. Ribavirin

InChI:InChI=1/C9H13N3O6/c1-17-9(16)7-10-3-12(11-7)8-6(15)5(14)4(2-13)18-8/h3-6,8,13-15H,2H2,1H3

Upstream product

• 13035-61-5 1,2,3,5-tetraacetylribose 
• 4928-88-5 methyl 1H-1,2,4-triazole-3-carboxylate 
• 58-63-9 inosine 
• 57198-04-6 1-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-1H-1,2,4-triazole-3-carboxylic acid methyl ester 

Downstream Products

• 36791-04-5 ribavirin 
• 594860-43-2 methyl 1-(2,3-O-isopropylidene-β-D-ribofuranosyl)-1,2,4-triazole-3-carboxylate 

Relevant articles and documents

A 1/10 water ribavirin compounds and pharmaceutical compositions thereof (by machine translation)

The invention discloses a 1/10 water ribavirin compounds and pharmaceutical compositions thereof, per mole of ribavirin compounds containing 1/10 mole water. Its infrared spectrum in the wave number is 3451.8 ± 2 cm- 1 , 3347.5 ± 2 cm- 1 , 2857.1 ± 2 cm- 1 , 1663.3 ± 2 cm- 1 , 1502.8 ± 2 cm- 1 , 1438.4 ± 2 cm- 1 , 1336.8 ± 2 cm- 1 , 1281.8 ± 2 cm- 1 , 1070.3 ± 2 cm- 1 , 892.8 ± 2 cm- 1 , 773.3 ± 2 cm- 1 , 672.0 ± 2 cm- 1 There is a characteristic absorption peak. The invention through crystallization of the ribavirin impact factors study and research of different crystallization solvent system, to prepare high purity, good stability 1/10 water RBV compound, and by this invention stated 1/10 water RBV compound preparation has good stability of the pharmaceutical composition. (by machine translation)

Preparation of L-ribavirin (by machine translation)

The invention provides a method for the preparation of ribavirin, to inosine as raw materials, after acetylation, condensation, aminolysis step to obtain the target product, the alkali in the acylation reaction of aluminum trichloride as a catalyst is conducted under the condition of, said condensation is in the NaI is conducted under the conditions of the catalyst, the aminolysis in methanol of existence of the sodium is conducted under the condition of. The method improves the acetylation efficiency, improves the yield of target product purity, shortens the reaction time, more easy to operate, is very suitable for industrial application. (by machine translation)

Synthesis of Azole Nucleoside 5′-Monophosphate Mimics (P1Ms) and Their Inhibitory Properties of IMP Dehydrogenases

IMPDH inhibitors have potential antimicrobial, anticancer and immunomodulatory effects. Nucleoside inhibitors of IMPDH exert their inhibitory effects via nucleoside 5′-MPs. Conversion of nucleoside analogs to NMPs by cellular nucleoside kinases is not ass