38939-64-9

Basic information

• Product Name: 2-(4-PyridinylMethoxy)-1H-Iioindole-1,3(2H)-dione
• Synonyms: 2-(4-PyridinylMethoxy)-1H-Iioindole-1,3(2H)-dione
• CAS NO: 38939-64-9
• Molecular Formula: C14H10N2O3
• Molecular Weight: 254.2408
• Mol File: 38939-64-9.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 445.0±47.0 °C(Predicted)
• Appearance: /
• Density: 1.41±0.1 g/cm3(Predicted)
• PKA: 5.05±0.10(Predicted)
• CAS DataBase Reference: 2-(4-PyridinylMethoxy)-1H-Iioindole-1,3(2H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-PyridinylMethoxy)-1H-Iioindole-1,3(2H)-dione(38939-64-9)
• EPA Substance Registry System: 2-(4-PyridinylMethoxy)-1H-Iioindole-1,3(2H)-dione(38939-64-9)

Safety Data

• Hazardous Substances Data: 38939-64-9(Hazardous Substances Data)

Usage

General Description

2-(4-PyridinylMethoxy)-1H-Iioindole-1,3(2H)-dione, also known as Olprinone, is a chemical compound belonging to the class of phosphodiesterase inhibitors. It has been studied for its potential therapeutic benefits in the treatment of heart failure and other cardiovascular conditions. Olprinone works by inhibiting the breakdown of cyclic adenosine monophosphate (cAMP), a molecule that plays a role in regulating heart and blood vessel function. By increasing cAMP levels, Olprinone may help to improve heart function and reduce symptoms of heart failure. Research on Olprinone continues to explore its potential applications and benefits in the field of cardiology and cardiovascular medicine.

Upstream product

• 586-95-8 pyridine-4-methanol 
• 524-38-9 N-hydroxyphthalimide 

Downstream Products

• 16115-54-1 O-(pyridin-4-ylmethyl)hydroxylamine dihydrochloride 

Relevant articles and documents

SUBSTITUTED GUANIDINE DERIVATIVE

The present invention provides a compound of general formula (I) (wherein, R1, X, p and q are as described in the present description and claims), or a pharmacologically acceptable salt thereof, and a pharmaceutical composition containing that compound.

PHARMACEUTICAL COMPOSITION CONTAINING TRICYCLIC COMPOUND HAVING SULFINYL OR SULFONYL

PROBLEM TO BE SOLVED: To provide a pharmaceutical composition that has antibacterial activity against carbapenem-resistant bacteria. SOLUTION: A pharmaceutical composition contains a compound represented by formula (I), its ester body or their pharmaceutically acceptable salts, or their hydrates (W is S(=O) or S(=O)2; T is CR4AR4B or CR5AR5B-CR6AR6B; R4A, R4B, R5A, R5B, R6A and R6B independently represent halogen, hydroxy, carbonyl, alkyl, cycloalkyl, aryl or the like; R1 is a carbocycle or heterocycle; R2A and R2B independently represent H, amino, hydroxy and the like, or R2A and R2B together form methylidene, hydroxyimino and the like; R3 is H, methoxy or the like). SELECTED DRAWING: None COPYRIGHT: (C)2018,JPOandINPIT

Carbamates of rapamycin

A compound of the structure STR1 wherein R1 and R2 are each, independently, hydrogen, or --CONH--O--(CR3 R4)m Z; R3 and R4 are each, independently, hydrogen, alkyl, cycloalkyl, --CF3, or F; Z is hydrogen, alkyl, --OR5, --SR5, --NRSR6, --CN, --CF3, --OAr, --Ar, or R7 ; R5 and R6 are each, independently, hydrogen, alkyl, arylalkyl, alkenyl, alkynyl, alkoxyalkyl, alkylthioalkyl, alkylaminoalkyl, dialkylaminoalkyl, cycloalkyl, or Ar; R7 STR2 or --C C--R11 ; R8, R9, R10, and R11 are each, independently, hydrogen, alkyl of 1-6 carbon atoms, halogen, or phenyl, wherein the phenyl group may be optionally mono-, di-, or tri-substituted; Ar is an aryl radical that may be optionally mono-, di-, or tri-substituted; and m=1-6; with the proviso that R1 and R2 are both not hydrogen, or a pharmaceutically acceptable salt thereof which is useful as an immunosuppressive, antiinflammatory, antifungal, antiproliferative, and antitumor agent.