38941-36-5

Basic information

• Product Name: N-(imidazolidin-2-ylidene)benzylamine
• Synonyms: N-(imidazolidin-2-ylidene)benzylamine
• CAS NO: 38941-36-5
• Molecular Weight: 175.233
• Mol File: 38941-36-5.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: N-(imidazolidin-2-ylidene)benzylamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(imidazolidin-2-ylidene)benzylamine(38941-36-5)
• EPA Substance Registry System: N-(imidazolidin-2-ylidene)benzylamine(38941-36-5)

Safety Data

• Hazardous Substances Data: 38941-36-5(Hazardous Substances Data)

Upstream product

• 5465-96-3 2-nitroamino-1,3-diazacyclopent-2-ene 
• 100-46-9 benzylamine 
• 54255-11-7 2-chloro-4,5-dihydro-1H-imidazole 
• 20112-79-2 2-methylthioimidazoline 
• 5464-11-9 2-methylthio-2-imidazoline hydroiodide 

Downstream Products

• 53360-98-8 2-[N-benzyl-N-(2-imidazolin-2-yl)amino]-4'-bromoacetophenone hydrobromide 
• 68020-61-1 7-amino-8-benzyl-6-formylamino-2,8-dihydro-3H-imidazo[1,2-a]pyrimidin-5-one 
• 68020-62-2 4-benzyl-1⁽³⁾,4,6,7-tetrahydro-imidazo[1,2-a]purin-9-one 

Relevant articles and documents

Facile guanidine formation under mild acidic conditions

An efficient method for converting isothioureas into guanidines was developed. The use of amine salts of bis(trifluoromethanesulfonyl)imide as a nitrogen source was found to induce an efficient conversion under weak acidic conditions at 50 °C. The conversion was applicable to the various amines and carbamate-protected thioureas, and various carbamate-protected cyclic guanidines were obtained in high yields. In particular, ammonium bis(trifluoromethanesulfonyl)imide salt is a useful N1 source with which to construct monoprotected cyclic guanidines.

C-N Bond forming reactions in the synthesis of substituted 2-aminoimidazole derivatives

Carbon-nitrogen bond forming reactions oriented to the synthesis of 2-amino-imidazolidines and imidazoles have been investigated. The C-2 amination of imidazolidinones, via the corresponding 2-chlorodihydroimidazoles, led to 2-benzylaminodihydroimidazole or bis(dihydroimidazole)amino derivatives by choosing the adequate experimental conditions. On the other hand, the use of N-acyl-2-methylsulfanyldihydroimidazoles allowed carrying out the reactions with aromatic amines, such as p-anisidine. Finally, palladium catalyzed Buchwald- Hartwig amination was the method of choice for C-N coupling between 2-haloimidazoles and aromatic amines in the synthesis of the corresponding imidazoles.

Substituted 6,7-dihydroimidazo[1,2-al]purin-9 (4H)-ones

The synthesis of a series of substituted 6,7-dihydroimidazo[1,2-a]purin-9(4H)-ones is described. Several members of the series exhibit enhanced antiallergic and bronchodilator activity and reduced side effects as compared to theophylline. Structure-activity relationships and metabolic considerations are discussed for the series. Analogues substituted with a 4-(4-chlorobenzyl) moiety, such as 33 and 40, show an optimal balance of antiallergic and bronchodilator activity and are of particular interest. Compound 33 is significantly more potent than theophylline against both metacholine- and antigen-induced bronchospasms, does not affect spontaneous motor activity, and shows minimal cardiovascular effects in the rat.