3898-47-3

Basic information

• Product Name: phenyl butylcarbamate
• Synonyms: Carbamic acid, butyl-, phenyl ester; carbamic acid, N-butyl-, phenyl ester; Phenyl butylcarbamate
• CAS NO: 3898-47-3
• Molecular Formula: C₁₁H₁₅NO₂
• Molecular Weight: 193.2423
• Mol File: 3898-47-3.mol
• Article Data: 19

Chemical Properties

• Boiling Point: 270.5°C at 760 mmHg
• Flash Point: 117.4°C
• Density: 1.042g/cm³
• Vapor Pressure: 0.00681mmHg at 25°C
• Refractive Index: 1.506
• CAS DataBase Reference: phenyl butylcarbamate(CAS DataBase Reference)
• NIST Chemistry Reference: phenyl butylcarbamate(3898-47-3)
• EPA Substance Registry System: phenyl butylcarbamate(3898-47-3)

Safety Data

• Hazardous Substances Data: 3898-47-3(Hazardous Substances Data)

Usage

General Description

Phenyl butylcarbamate, also known as butylphenyl methylpropional, is a chemical compound commonly used as a preservative in cosmetic and personal care products. It is also found in many household and industrial products. Phenyl butylcarbamate is known for its antimicrobial properties, which help to prolong the shelf life of these products by inhibiting the growth of bacteria and fungi. However, it can also cause skin irritation and allergic reactions in some individuals, leading to concerns about its safety and potential health risks. As a result, some companies and regulatory agencies have restricted or banned its use in certain products.

Upstream product

• 102-09-0 bis(phenyl) carbonate 
• 109-73-9 N-butylamine 
• 1202680-24-7 phenyl 4,5-dichloro-6-oxopyridazine-1(6H)-carboxylate 
• 1885-14-9 phenyl chloroformate 
• 108-95-2 phenol 
• 73330-93-5 Methyl N-n-butylthiocarbamate 
• 41755-73-1 phenyl 2-hydroxy-3-methylbenzoate 
• 111-36-4 n-butyl isocyanide 
• 33454-09-0 phenyl 2-hydroxy-4-methoxybenzoate 
• 118-55-8 phenyl Salicylate 
• 35180-03-1 chloromethyl phenyl carbonate 

Downstream Products

• 64-77-7 N-[(butylamino)carbonyl]-4-methyl-benzenesulfonamide 
• 25544-79-0 ethyl 2-(butylcarbamoyl)hydrazine-1-carboxylate 
• 108-95-2 phenol 
• 20605-19-0 4-butyl-3-semicarbazide 
• 111-36-4 n-butyl isocyanide 

Relevant articles and documents

Rapid Multigram-Scale End-to-End Continuous-Flow Synthesis of Sulfonylurea Antidiabetes Drugs: Gliclazide, Chlorpropamide, and Tolbutamide

A multigram-scale robust, efficient, and safe end-to-end continuous-flow process for the diabetes sulfonylurea drugs gliclazide, chlorpropamide, and tolbutamide is reported. The drugs were prepared by the treatment of an amine with a haloformate affording carbamate, which was subsequently treated with a sulfonamide to afford sulfonylurea. Gliclazide was obtained in 87% yield within 2.5 minutes total residence time with 26 g/h throughput; 0.2 kg of the drug was produced in 8 hours of running the system continuously. Chlorpropamide and tolbutamide were both obtained in 94% yield within 1 minute residence time with 184-188 g/h throughput; 1.4-1.5 kg of the drugs was produced in 8 hours of running the system continuously. N-Substituted carbamates were used as safe alternatives to the hazardous isocyanates in constructing the sulfonyl urea moiety.

A facile synthesis of sulfonylureas: Via water assisted preparation of carbamates

A novel and simple approach to the synthesis of sulfonylureas has been reported. It involved the reaction of various amines with diphenyl carbonate to yield the corresponding carbamates, which subsequently reacted with different sulphonamides to produce different sulfonylureas in excellent yields. The first reaction of diphenyl carbonate with amines was carried out in aqueous:organic (H2O:THF, 90:10) medium at room temperature to produce carbamates that paved a straightforward route to sulfonylureas after reaction with sulfonamides. The above process avoided traditional multistep protocols and the use of hazardous, irritant, toxic and moisture sensitive reagents such as phosgene, isocyanates and/or chloroformates.

Phenyl 4,5-dichloro-6-oxopyridazine-1(6H)-carboxylate as carbonyl source: Facile and selective synthesis of carbamates and ureas under mild conditions

The selective syntheses of carbamates, symmetric -ureas, and unsymmetrical ureas have been accomplished by the -reaction of amines with phenyl 4,5-dichloro-6-oxopyridazine-1(6H)-carboxylate as a carbonyl source under mild conditions. It is noteworthy that this process is mild, economic, and convenient.