39024-57-2 Usage
Description
PYR-GLY-PRO-TRP-LEU-GLU-GLU-GLU-GLU-GLU-ALA-TYR-GLY-TRP-LEU-ASP-PHE-NH2, also known as [Leu15]-Gastrin I, is a peptide hormone encoded by the GAST gene located on human chromosome 17q21.2. It is produced by G cells in the stomach antrum as progastrin, which undergoes cleavage and processing to yield gastrin. Gastrin plays a crucial role in the growth and development of the gastrointestinal epithelium and stimulates the production of gastric acid by parietal cells. It exerts its function through the G-protein-coupled receptor, cholecystokinin (CCK) or CCK-B receptor (CCK-BR).
Uses
Used in Pharmaceutical Applications:
PYR-GLY-PRO-TRP-LEU-GLU-GLU-GLU-GLU-GLU-ALA-TYR-GLY-TRP-LEU-ASP-PHE-NH2 is used as a medium supplement for establishing enteroid cultures and as a supplement to standard Dulbecco's Modified Eagle Medium (DMEM) culture medium, human minigut medium to establish the growth of crypts.
Used in Research and Development:
PYR-GLY-PRO-TRP-LEU-GLU-GLU-GLU-GLU-GLU-ALA-TYR-GLY-TRP-LEU-ASP-PHE-NH2 is used as a research tool for studying the role of gastrin in the gastrointestinal system, its interaction with the CCK-BR, and its potential involvement in conditions such as atrophic gastritis, Helicobacter pylori infection, and gastric adenocarcinoma.
Used in Diagnostic Applications:
PYR-GLY-PRO-TRP-LEU-GLU-GLU-GLU-GLU-GLU-ALA-TYR-GLY-TRP-LEU-ASP-PHE-NH2 can be used as a diagnostic marker for conditions related to gastrin overexpression, such as atrophic gastritis and gastric adenocarcinoma, by measuring its levels in patient samples.
Used in the Food Industry:
PYR-GLY-PRO-TRP-LEU-GLU-GLU-GLU-GLU-GLU-ALA-TYR-GLY-TRP-LEU-ASP-PHE-NH2 may be used as a component in the development of novel food products or supplements targeting gastrointestinal health, as it plays a role in the growth and development of the gastrointestinal epithelium and stimulates gastric acid production.
Used in Drug Development:
PYR-GLY-PRO-TRP-LEU-GLU-GLU-GLU-GLU-GLU-ALA-TYR-GLY-TRP-LEU-ASP-PHE-NH2 could be a potential target for drug development, focusing on modulating its activity or interaction with the CCK-BR to treat conditions related to gastrin overexpression or dysfunction.
Biochem/physiol Actions
Gastrin I analog with full biological activity and improved stability in aqueous solutions. Leu15 replaces Met15, that is readily oxidized resulting in loss of biological activity.
Check Digit Verification of cas no
The CAS Registry Mumber 39024-57-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,9,0,2 and 4 respectively; the second part has 2 digits, 5 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 39024-57:
(7*3)+(6*9)+(5*0)+(4*2)+(3*4)+(2*5)+(1*7)=112
112 % 10 = 2
So 39024-57-2 is a valid CAS Registry Number.
InChI:InChI=1/C98H128N20O31/c1-49(2)38-68(115-96(147)72(43-55-46-101-60-19-12-10-17-58(55)60)117-98(149)74-20-13-37-118(74)77(122)48-103-86(137)61-25-31-75(120)105-61)93(144)111-66(30-36-82(131)132)92(143)110-65(29-35-81(129)130)91(142)109-64(28-34-80(127)128)90(141)108-63(27-33-79(125)126)89(140)107-62(26-32-78(123)124)88(139)104-51(5)85(136)113-70(41-53-21-23-56(119)24-22-53)87(138)102-47-76(121)106-71(42-54-45-100-59-18-11-9-16-57(54)59)95(146)114-69(39-50(3)4)94(145)116-73(44-83(133)134)97(148)112-67(84(99)135)40-52-14-7-6-8-15-52/h6-12,14-19,21-24,45,49-51,55,61-74,100-101,119H,13,20,25-44,46-48H2,1-5H3,(H2,99,135)(H,102,138)(H,103,137)(H,104,139)(H,105,120)(H,106,121)(H,107,140)(H,108,141)(H,109,142)(H,110,143)(H,111,144)(H,112,148)(H,113,136)(H,114,146)(H,115,147)(H,116,145)(H,117,149)(H,123,124)(H,125,126)(H,127,128)(H,129,130)(H,131,132)(H,133,134)
