39070-97-8

Basic information

• Product Name: (4-methoxyphenyl)(naphthalen-2-yl)methanone
• CAS NO: 39070-97-8
• Molecular Formula: C₁₈H₁₄O₂
• Molecular Weight: 262.3026
• Mol File: 39070-97-8.mol
• Article Data: 26

Chemical Properties

• Boiling Point: 439.6°C at 760 mmHg
• Flash Point: 202°C
• Density: 1.162g/cm³
• Vapor Pressure: 6.3E-08mmHg at 25°C
• Refractive Index: 1.632
• CAS DataBase Reference: (4-methoxyphenyl)(naphthalen-2-yl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: (4-methoxyphenyl)(naphthalen-2-yl)methanone(39070-97-8)
• EPA Substance Registry System: (4-methoxyphenyl)(naphthalen-2-yl)methanone(39070-97-8)

Safety Data

• Hazardous Substances Data: 39070-97-8(Hazardous Substances Data)

Usage

General Description

(4-methoxyphenyl)(naphthalen-2-yl)methanone, also known as 4-Methoxy-1-naphthaldehyde, is a chemical compound with the molecular formula C19H14O2. It is a ketone compound with a naphthalene ring and a methoxyphenyl group attached to it. (4-methoxyphenyl)(naphthalen-2-yl)methanone is used in various chemical and pharmaceutical applications, including as an intermediate in the synthesis of other organic compounds. It has also been studied for its potential pharmacological and biological activities. However, as with any chemical compound, it is important to handle and use (4-methoxyphenyl)(naphthalen-2-yl)methanone with caution and according to proper safety protocols.

Upstream product

• 5720-07-0 4-methoxyphenylboronic acid 
• 82408-29-5 phenyl naphthalene-2-carboxylate 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 113443-62-2 N-methoxy-N-methylnaphthalene-2-carboxamide 
• 66-99-9 β-naphthaldehyde 
• 67-66-3 chloroform 
• 696-62-8 para-iodoanisole 
• 32316-92-0 naphthalene-2-boronic acid 
• 213596-33-9 2-(4-methoxyphenyl)-5,5-dimethyl-1,3,2-dioxaborolane 
• 100-07-2 4-methoxy-benzoyl chloride 
• 612-55-5 2-iodonaphthalene 
• 2243-82-5 2-naphthamide 
• 93296-09-4 4-methoxyphenylzinc chloride 
• 123-11-5 4-methoxy-benzaldehyde 

Downstream Products

• 102599-41-7 1-(4-methoxy-phenyl)-1-[2]naphthyl-pent-2-yne-1,5-diol 
• 859181-48-9 1,2-bis-(4-methoxy-phenyl)-1,2-di-[2]naphthyl-ethane-1,2-diol 
• 32891-91-1 2-(4-methoxy-benzyl)-naphthalene 
• 39070-83-2 (4-Hydroxy-3,5-diiodo-phenyl)-naphthalen-2-yl-methanone 
• 39070-82-1 (3,5-Dibromo-4-hydroxy-phenyl)-naphthalen-2-yl-methanone 
• 87643-54-7 p-methoxyphenyl 2-naphthyl thioketone 
• 39070-90-1 (4-hydroxyphenyl)(naphthalen-2-yl)methanone 

Relevant articles and documents

Synthesis of biaryl ketones by arylation of Weinreb amides with functionalized Grignard reagents under thermodynamic controlvs.kinetic control ofN,N-Boc2-amides

A highly efficient method for chemoselective synthesis of biaryl ketones by arylation of Weinreb amides (N-methoxy-N-methylamides) with functionalized Grignard reagents is reported. This protocol offers rapid entry to functionalized biaryl ketones after Mg/halide exchange with i-PrMgCl·LiCl under operationally-simple and practical reaction conditions. The scope of the method is highlighted in >40 examples, including bioactive compounds and pharmaceutical derivatives. Collectively, this transition-metal-free approach offers a major advantage over the recently established cross-coupling of amides by oxidative addition of N-C(O) bonds. Considering the utility of amide acylation reactions in modern synthesis, we expect that this method will be of broad interest.

COMPOUND FOR ORGANIC SYNTHETIC REACTION

PROBLEM TO BE SOLVED: To provide a compound for organic synthetic reaction capable of reducing unnecessary reaction byproduct and generating a targeted chemical reaction effectively, even when a base compound sensitive to basicity is used. SOLUTION: There is provided a compound for organic synthetic reaction which is used for a coupling reaction or an addition reaction forming a bond between carbon-carbon, and is a compound represented by the structure formula (1) or a salt thereof. In the formula, (A) represents an oxygen atom or a nitrogen atom, R1 represents a substituent containing one or more carbon atom, R2 represents a substituent containing one or more carbon atom, hydrogen or halogen, and R1 and R2 may be the same or different each other. SELECTED DRAWING: Figure 2 COPYRIGHT: (C)2019,JPOandINPIT

N-Acylsuccinimides: Efficient acylative coupling reagents in palladium-catalyzed Suzuki coupling via C–N cleavage

An acylative Suzuki coupling of activated amides with aryl boronic acids has been reported via palladium-catalyzed C–N bond cleavage. This protocol demonstrate amides can be activated by an atom-economic and cheap succinimide, which can be efficiently utilized to synthesize broad array of diaryl ketones in moderate to good yields.