39093-27-1

Basic information

• Product Name: N-METHYL N-NONYLAMINE
• Synonyms: N-methylnonylamine;N-METHYL N-NONYLAMINE;1-nonanamine,N-methyl-;methylnonylamine;N-Methyl-1-nonanamine
• CAS NO: 39093-27-1
• Molecular Formula: C₁₀H₂₃N
• Molecular Weight: 157.3
• Mol File: 39093-27-1.mol
• Article Data: 7

Chemical Properties

• Melting Point: -38.5°C (estimate)
• Boiling Point: 202°C (estimate)
• Appearance: /
• Density: 0.7790
• Refractive Index: 1.4317
• CAS DataBase Reference: N-METHYL N-NONYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: N-METHYL N-NONYLAMINE(39093-27-1)
• EPA Substance Registry System: N-METHYL N-NONYLAMINE(39093-27-1)

Safety Data

• Hazardous Substances Data: 39093-27-1(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Tetrahedron Letters, 30, p. 7383, 1989 DOI: 10.1016/S0040-4039(00)70703-9

Upstream product

• 6212-93-7 N-Methylpelargonamide 
• 51-80-9 bis-(dimethylamino)methane 
• 111-66-0 oct-1-ene 
• 629-27-6 1-Iodooctane 
• 112-29-8 1-bromo dodecane 
• 74-89-5 methylamine 
• 17049-49-9 octylmagnesium bromide 
• 68579-57-7 7,7,9,9-tetramethyl-1,4-dioxa-8-aza-spiro[4.5]decane-8-carboxylic acid methyl-nonyl-amide 
• 4282-42-2 1-iodononane 
• 114084-69-4 N-benzyl-N-methylnonamine 
• 693-58-3 1-Bromononane 
• 74-88-4 methyl iodide 

Downstream Products

• 24552-02-1 N-methyl-N-octylnonan-1-amine 

Relevant articles and documents

IONIZABLE LIPIDS AND NANOPARTICLE COMPOSITIONS THEREOF

Provided herein are ionizable lipids represented by the Formula (I): or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, R1, R2, R3, R4, R5,R6, m, and n are as defined herein. Also provided herein are lipid nanoparticle (LNP) compositions comprising an ionizable lipid of the invention and a capsid-free, non-viral vector (e.g., ceDNA). These LNPs can be used to deliver a capsid-free, non-viral DNA vector to a target site of interest (e.g., cell, tissue, organ, and the like).

Synthesis method of N-methylamine compound

The invention discloses a synthesis method of an N-methylamine compound. The synthesis method is characterized in that a carbamyl imidazole compound is used as a raw material; a NaBH4/I2 is used for performing backflow in tetrahydrofuran to prepare an N-methyl structure compound. The used reduction system NaBH4/I2 has the advantages of environment-friendly effect, performance stability, high conversion rate and the like. The synthesis method has the beneficial effects that (1) the synthesis method has wide applicability; amine can be used as the raw material; carboxylic acid can also be used as the raw material; (2) the product yield is high and reaches as high as 82 percent; (3) a synthetic agent is simple and can be easily obtained; the cost is low; the process is simple; the reaction conditions are mild; the synthesis method is suitable for industrial production. A concrete reaction formula is shown in the description, wherein R1 and R2 are identical or different atoms or groups, and are respectively and independently selected from one of hydrogen atoms, C1-C20 straight-chain or branch-chain alkane, C5-C10 naphthenic groups, aryl groups and substituted aryl groups; monosubstitution or multi-substitution is performed on aromatic rings of the substituted aryl groups. In addition, KBH4 is also applicable to the reaction.

ALKYLAMINOMETHYLATION D'ORGANOMAGNESIENS.

The organomagnesium compound RMgX is converted, in two steps, into the secondary amine R-CH2-NH-R1 (R1=CH3 or alkyl).