39123-65-4

Basic information

• Product Name: 3-BENZYL-2-MERCAPTO-3,5-DIHYDRO-4H-IMIDAZOL-4-ONE
• Synonyms: 3-BENZYL-2-MERCAPTO-3,5-DIHYDRO-4H-IMIDAZOL-4-ONE;3-Benzyl-2-Mercapto-3,5-dihydro-iMidazol-4-one;3-benzyl-2-sulfanylideneimidazolidin-4-one
• CAS NO: 39123-65-4
• Molecular Formula: C₁₀H₁₀N₂OS
• Molecular Weight: 206.26
• Mol File: 39123-65-4.mol
• Article Data: 11

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-BENZYL-2-MERCAPTO-3,5-DIHYDRO-4H-IMIDAZOL-4-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-BENZYL-2-MERCAPTO-3,5-DIHYDRO-4H-IMIDAZOL-4-ONE(39123-65-4)
• EPA Substance Registry System: 3-BENZYL-2-MERCAPTO-3,5-DIHYDRO-4H-IMIDAZOL-4-ONE(39123-65-4)

Safety Data

• Hazardous Substances Data: 39123-65-4(Hazardous Substances Data)

Upstream product

• 622-78-6 Benzyl isothiocyanate 
• 56-40-6 glycine 
• 100-46-9 benzylamine 
• 616-34-2 methoxycarbonylmethylamine 
• 5680-79-5 glycine ethyl ester hydrochloride 
• 100-44-7 benzyl chloride 
• 1399859-85-8 N-benzyl-N'-(2'-acetamido)thiourea 
• 134124-35-9 N-Benzyl-N'-(carboxymethyl)thiourea 

Downstream Products

• 23269-10-5 1-benzyl-1H-imidazole-2-thione 
• 110074-53-8 C₅H₅Ti(C₆H₅CH₂C₃H₂N₂OS)Cl₂ 
• 110074-54-9 C₅H₅Ti(C₆H₅CH₂C₃H₂N₂OS)2Cl 
• 110074-55-0 C₅H₅Ti(C₆H₅CH₂C₃H₂N₂OS)3 
• 1356003-68-3 (4Z)-1-benzyl-4-(4-methoxybenzylidene)-2-(4-methoxyphenyl)-4,5-dihydro-1H-imidazol-5-one 
• 875424-21-8 (5Z)-3-benzyl-5-(4-methoxybenzylidene)-2-thiohydantoin 
• 287198-16-7 3-benzyl-2-(methylsulfanyl)-3,5-dihydro-4H-imidazol-4-one 
• 91025-37-5 ethyl 3-benzyl-2-sulfanylidene-2,3-dihydro-1H-imidazole-4-carboxylate 
• 1609282-78-1 1-benzyl-2-(methylthio)-5-imidazolcarbonitrile 
• 80304-50-3 1-benzyl-5-hydroxymethylimidazole 

Relevant articles and documents

Novel synthesis of 3-substituted 2-thiohydantoins via aza-Wittig reaction on poly(ethylene glycol)

A novel method for the liquid-phase combinatorial synthesis of 3-substituted-2-thiohydantoin has been developed by using poly (ethylene glycol)-supported isothiocyanate. The PEG-supported isothiocyanate was obtained from the reaction of PEG with bromoacet

HETEROCYCLIC INTEGRIN AGONISTS

The present invention provides polycyclic oxothioxoimidazolidines, dioxoimidazolines, oxothioxooxazolidines, dioxooxazolidines, and related compounds, which are useful as integrin agonists. Methods for the treatment of integrin-mediated diseases such as cancer are also described.

Preparation of 2'-13c-l-histidine starting from 13c-thiocyanate: Synthetic access to any site-directed stable isotope enriched l-histidine

1-Benzyl-2-(methylthio)-imidazole-5-ketone is obtained in a few simple steps starting from thiocyanate and glycine amide (glycin). Subsequent treatment with diethyl phosphorocyanidate and functional group manipulations gives 1-benzyl-5-chloromethylimidazolium chloride. This compound is converted under mild O'Donnell conditions into the corresponding L-histidine derivative. After deprotection L-histidine is obtained in good yield and 99% enantiomeric excess. 2'-13C-L-Histidine has been obtained via this new scheme with high (99%) 13C incorporation starting with commercially available 13C- thiocyanate. This synthetic scheme allows access to any isotopomer of L-histidine and many other biologically important imidazole derivatives.