39136-60-2

Basic information

• Product Name: 5-Ethylthiazol-2-amine
• Synonyms: 5-Ethylthiazol-2-amine;5-ethyl-1,3-thiazol-2-amine
• CAS NO: 39136-60-2
• Molecular Formula: C₅H₈N₂S
• Molecular Weight: 128.19542
• Mol File: 39136-60-2.mol
• Article Data: 8

Chemical Properties

• Melting Point: 59 °C
• Boiling Point: 241.88 °C at 760 mmHg
• Flash Point: 100.086 °C
• Appearance: /
• Density: 1.196 g/cm³
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 5.37±0.10(Predicted)
• CAS DataBase Reference: 5-Ethylthiazol-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Ethylthiazol-2-amine(39136-60-2)
• EPA Substance Registry System: 5-Ethylthiazol-2-amine(39136-60-2)

Safety Data

• Hazardous Substances Data: 39136-60-2(Hazardous Substances Data)

Usage

General Description

5-Ethylthiazol-2-amine is a chemical compound with the molecular formula C5H9NS. It is a derivative of thiazole and contains an ethyl group attached to the carbon atom in the 5-position. 5-Ethylthiazol-2-amine is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It has also been studied for its potential biological activities, including antimicrobial and antifungal properties. The presence of the thiazole ring in the structure of 5-Ethylthiazol-2-amine makes it a unique and important molecule in the field of medicinal chemistry and drug development.

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Downstream Products

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Relevant articles and documents

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Synthesis and biological activity evaluation of 1,2,3-thiadiazole derivatives as potential elicitors with highly systemic acquired resistance

Elicitors provide a broad spectrum of systemic acquired resistance by altering the physical and physiological status of the host plants and, therefore, are among the most successful directions in modern pesticide development for plant protection. To develop a novel elicitor with highly systemic acquired resistance, two series of thiazole- and oxadiazole-containing thiadiazole derivatives were rationally designed and synthesized according to the principle of combination of bioactive substructures in this work. Their structures were characterized by 1H nuclear magnetic resonance (NMR), infrared (IR), high-resolution mass spectrometry (HRMS), or elemental analysis. Their potential systemic acquired resistance as an elicitor was also evaluated; bioassay results indicated that, among the 23 compounds synthesized, three compounds, 10a, 10d, and 12b, displayed better systemic acquired resistance than the positive control, tiadinil, a commercialized 1,2,3-thiadiazolebased elicitor. In addition, three other compounds, 10f, 12c, and 12j, exhibited a certain degree of fungus growth inhibition In vitro or In vivo. Our results demonstrated that, in combination of bioactive substructures is an interesting exploration for novel pesticide development, thiazole-and oxadiazole-containing thiadiazole derivatives are potential elicitors with good systemic acquired resistance.

IMIDAZO (1, 2-A) PYRIDINE COMPOUNDS AS VEGF-R2 INHIBITORS

The present invention provides compounds that are inhibitors of VEGF-R2 of the formula: (I) and methods of using these compounds.