39156-67-7

Basic information

• Product Name: DIHYDROCYTOCHALASIN B
• Synonyms: DIHYDROCYTOCHALASIN B;CYTOCHALASIN B, DIHYDRO;7(S),20(R)-dihydroxy-16(R)-methyl-10-phenyl-24-oxa[14]cytochalasa-6(12),13(E)-diene-1,23-dione;(7S,13E,16R,20R)-7,20-Dihydroxy-16-methyl-10-phenyl-24-oxa[14]cytochalasa-6(12),13-diene-1,23-dione;(7S,13E,16R,20R)-7β,20-Dihydroxy-16-methyl-10-phenyl-24-oxa[14]cytochalasa-6(12),13-diene-1,23-dione;21,22-Dihydrocytochalalsin B;DHCB;Dihidrocytochalasin B
• CAS NO: 39156-67-7
• Molecular Formula: C₂₉H₃₉NO₅
• Molecular Weight: 481.62
• EINECS: 254-324-4
• Product Categories: Actin Inhibitors and Probes;Cell Signaling and Neuroscience;Cytoskeleton and Extracellular Matrix;antibiotic
• Mol File: 39156-67-7.mol
• Article Data: 2

Chemical Properties

• Melting Point: 203-205 °C
• Boiling Point: 727.5 °C at 760 mmHg
• Flash Point: 393.8 °C
• Appearance: /
• Density: 1.19 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.584
• Storage Temp.: −20°C
• PKA: 13.65±0.70(Predicted)
• CAS DataBase Reference: DIHYDROCYTOCHALASIN B(CAS DataBase Reference)
• NIST Chemistry Reference: DIHYDROCYTOCHALASIN B(39156-67-7)
• EPA Substance Registry System: DIHYDROCYTOCHALASIN B(39156-67-7)

Safety Data

• Hazard Codes: T+,T
• Statements: 26/27/28-40
• Safety Statements: 22-36/37/39-45
• RIDADR: UN 2811 6.1/PG 2
• WGK Germany: 3
• RTECS: RO0205000
• HazardClass: 6.1(a)
• PackingGroup: I
• Hazardous Substances Data: 39156-67-7(Hazardous Substances Data)

Usage

Chemical Properties

white powder

Uses

Dihydrocytochalasin B is a cell morphology and motility and inducer.

InChI:InChI=1/C29H39NO5/c1-18-9-7-13-22(31)15-16-25(32)35-29-23(14-8-10-18)27(33)20(3)19(2)26(29)24(30-28(29)34)17-21-11-5-4-6-12-21/h4-6,8,11-12,14,18-19,22-24,26-27,31,33H,3,7,9-10,13,15-17H2,1-2H3,(H,30,34)/b14-8+/t18-,19-,22+,23-,24-,26+,27+,29-/m0/s1

Upstream product

• 14930-96-2 Phomin 
• 14110-64-6 cytochalasin A 
• 14930-96-2 cytochalasin B 
• 14930-96-2 cytochalasin B 

Downstream Products

• 39156-72-4 7β,20β-dimethoxy-2,16α-dimethyl-10-phenyl-24-oxa-[14]cytochalasa-6(12),13t-diene-1,23-dione 
• 39156-71-3 7β,20β-dimethoxy-16α-methyl-10-phenyl-24-oxa-[14]cytochalasa-6(12),13t-diene-1,23-dione 

Relevant articles and documents

CYTOCHALASINS: STRUCTURE-ACTIVITY RELATIONSHIPS

Seven cytochalasins, 7-O-acetylcytochalasin A and two derivatives of cytochalasin B were assayed for Pseudomonas syringae, Bacillus megaterium, and for Geotrichum candidum.Their ability to inhibit the growth of tomato seedlings and their toxicity to brine shrimp (percent larvae mortality) were also investigated.Among the compounds assayed only cytochalasin A showed antibiotic and fungicidal activity.Toxicity to tomato seedlings was exhibited by both - and -macrocyclic cytochalasins, while the activity decreased in the derivatives acetylated on the 7-hydroxy groupand markedly in cytochalasin E.In the brine shrimp bioassay, cytochalasin E was the most active mycotoxin, but generally, at low concentrations, the cytochalasins with the -macrocyclic ring were more active than those with the -macrocyclic ring; cytochalasin A appeared to be the most toxic.