39161-84-7

Basic information

• Product Name: 4-MERCAPTOPHENYLACETIC ACID
• Synonyms: 4-MERCAPTOBENZENEACETATE;4-MERCAPTOPHENYLACETIC ACID;4-Mercaptophenylacetic acid 97%;4-Mercaptophenylacetic acid≥ 98% (HPLC);Benzeneacetic acid,4-mercapto-;4-Mercaptophenylacetic Acid ( MPAA);2-(4-sulfanylphenyl)acetic acid;MPAA
• CAS NO: 39161-84-7
• Molecular Formula: C₈H₈O₂S
• Molecular Weight: 168.21
• Product Categories: Aromatic Phenylacetic Acids and Derivatives;Intermediates;Sulfur & Selenium Compounds;Organic Building Blocks;Sulfur Compounds;Thiols/Mercaptans
• Mol File: 39161-84-7.mol
• Article Data: 13

Chemical Properties

• Melting Point: 105-109 °C(lit.)
• Boiling Point: 336 °C at 760 mmHg
• Flash Point: 157 °C
• Appearance: White Powder
• Density: 1.299 g/cm³
• Vapor Pressure: 4.54E-05mmHg at 25°C
• Refractive Index: 1.62
• Storage Temp.: -20°C Freezer, Under Inert Atmosphere
• PKA: 4.21±0.10(Predicted)
• Water Solubility: Slightly soluble in water. Soluble in Dichloromethane, Ethanol and Methanol
• Sensitive: Air Sensitive
• CAS DataBase Reference: 4-MERCAPTOPHENYLACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-MERCAPTOPHENYLACETIC ACID(39161-84-7)
• EPA Substance Registry System: 4-MERCAPTOPHENYLACETIC ACID(39161-84-7)

Safety Data

• Hazard Codes: Xi
• Statements: 37/38-41
• Safety Statements: 26-36/37/39
• RIDADR: UN 3335
• WGK Germany: 3
• Hazardous Substances Data: 39161-84-7(Hazardous Substances Data)

Usage

Chemical Properties

4-MERCAPTOPHENYLACETIC ACID is White Powder

Uses

Different sources of media describe the Uses of 39161-84-7 differently. You can refer to the following data:
1. 4-Mercaptophenylacetic acid has been used in the preparation of small ubiquitin-like modifier peptides from bis(2-sulfanylethyl)amido peptide via sequential native chemical ligation.It can be used: On-resin preparation of peptide-α thiophenylesters which are used in a chemical ligation process for the chemical synthesis of peptides.In one pot deprotection of (acetamido-methyl)cysteine following native chemical ligation and/or desulfurization method for the preparation of peptides.Palladium facilitated deprotection of N-terminal cysteine through native chemical ligation method for the preparation of synthetically challenging proteins.
2. 4-MERCAPTOPHENYLACETIC ACID is a redox buffer that increases the folding rate of disulfide-containing proteins realative to traditional buffers such as glutathione and glutathione-disulfide. A useful synthetic intermediate for the preparation of novel antiinflammatory agents.

InChI:InChI=1/C8H8O2S/c9-8(10)5-6-1-3-7(11)4-2-6/h1-4,11H,5H2,(H,9,10)

Upstream product

• 1197-55-3 4-aminophenylacetic acid 
• 1235544-51-0 2-(4-((ethoxycarbonothioyl)thio)phenyl)acetic acid 
• 22958-99-2 2-(4-(chlorosulfonyl)phenyl)acetic acid 
• 477256-87-4 (4-Dimethylthiocarbamoyloxy-phenyl)-acetic acid methyl ester 
• 14199-15-6 Methyl 4-hydroxyphenylacetate 
• 317319-11-2 (4-dimethylcarbamoylsulfanyl-phenyl)-acetic acid methyl ester 

Downstream Products

• 5325-76-8 2-[4-[[4-(carboxymethyl)phenyl]-disulfanyl]phenyl]acetic acid 
• 91361-92-1 (4-mercapto-phenyl)-acetic acid methyl ester 
• 1363179-27-4 propyl [4-(propylthio)phenyl]acetate 
• 383135-47-5 2-[4-(ethanesulfonyl)phenyl]acetic acid 
• 919853-65-9 2-[4-(ethylsulfonyl)phenyl]-N-[4-phenyl-5-(phenylcarbonyl)-1,3-thiazol-2-yl]acetamide 
• 1363178-84-0 2-[4-(ethylsulfonyl)phenyl]-2-methyl-N-[4-phenyl-5-(phenylcarbonyl)-1,3-thiazol-2-yl]propanamide 
• 1363179-14-9 methyl [4-(ethylsulfonyl)phenyl]acetate 
• 1363179-18-3 methyl 2-[4-(ethylsulfonyl)phenyl]propanoate 
• 1363179-16-1 2-(4-(ethylsulfonyl)phenyl)propanoic acid 
• 1363178-86-2 2-[4-(ethylsulfonyl)phenyl]-N-[4-phenyl-5-(phenylcarbonyl)-1,3-thiazol-2-yl]propanamide 
• 1361414-22-3 methyl 2-(4-((2,2,2-trifluoroethyl)thio)phenyl)acetate 
• 1361414-24-5 methyl 2-(4-((2,2,2-trifluoroethyl)sulfonyl)phenyl)acetate 
• 1153070-21-3 2-(4-((2,2,2-trifluoroethyl)sulfonyl)phenyl)acetic acid 
• 1363178-92-0 N-[4-phenyl-5-(phenylcarbonyl)-1,3-thiazol-2-yI]-2-{4-[(2,2,2-trifluoroethyl)sulfonyl]phenyl}acetamide 

Relevant articles and documents

SUBSTITUTED TETRAHYDROQUINOLINONE COMPOUNDS AS ROR GAMMA MODULATORS

The present invention provides substituted tetrahydroquinolinone and related compounds of formula (I), which are therapeutically useful as modulators of Retinoic acid receptor-related orphan receptors (RORs), more particularly as RORγ modulators. These co

FUSED THIOPHENE AND THIAZOLE DERIVATIVES AS ROR GAMMA MODULATORS

The present invention provides fused thiophene and thiazole derivatives of formula (I), which may be therapeutically useful, more particularly as RORγ modulators; in which R1, R2, R3, R4, R5, R6, R7, X1, X2, L, m, n and ring A have the meanings given in the specification, and pharmaceutically acceptable salts thereof that are useful in the treatment and prevention of diseases or disorders, in particular their use in disease(s) or disorder(s) where there is an advantage in modulating RORγ receptor. The present invention also provides preparation of the compounds and pharmaceutical formulations comprising at least one of the fused thiophene and thiazole derivatives of formula (I), together with a pharmaceutically acceptable carrier, diluent or excipient therefor.

TRISUBSTITUTED HETEROCYCLIC DERIVATIVES AS ROR GAMMA MODULATORS

The present invention provides trisubstituted heterocyclic derivatives of formula (I), which may be therapeutically useful, more particularly as RORγ modulators; (I) in which R1, R2, R3, Ra, X, L, m and ring A have the meanings given in the specification, and pharmaceutically acceptable salts thereof that are useful in the treatment and prevention of diseases or disorder, in particular their use in diseases or disorder where there is an advantage in modulating RORγ receptor. The present invention also provides preparation of the compounds and pharmaceutical formulations comprising at least one of the trisubstituted heterocyclic derivatives of formula (I) together with a pharmaceutically acceptable carrier, diluent or excipient therefor.