3919-49-1Relevant articles and documents
Dinaphthonaphthyridines - A class of novel molecules with potent antioxidant and anticancer activity
Prabha,Prasad, K. J. Rajendra
, p. 340 - 346 (2013)
A series of novel dinaphtho[1,2-b:1′,2′-h][1,6]naphthyridine derivatives bearing aliphatic, aromatic and heteroaromatic substituents at the C7 position were designed and synthesized conveniently from 4-chloro-2-methylbenzo[h]quinoline. All compounds were screened for in vitro antioxidant activities against DPPH, ABTS+, superoxide and hydroxyl radicals. Among the compounds screened, 13, 15, 16, 19 and 20 showed excellent antioxidant activity against OH. In addition, the cytotoxicity of the dinaphthonaphthyridine derivatives was evaluated by MTT assay and compared with Adriamycin. From screening, we identified that compounds 6, 16 and 20 showed IC50s ranging from 1.20 to 5.61 μM for growth inhibition of HeLa, HCT116 and AGS cancer cell lines. The results documented that varying of the chemical entity at C7 can fine-tune the enhancement of cell growth inhibition strategy. The Royal Society of Chemistry.
Microwave-assisted Synthesis of 2-methyl-4-quinolinones via combes synthesis catalyzed by acidic resin under solvent-free condition
Yuan, Shizhen,Zhang, Kehua,Xia, Jingjing
, p. 5535 - 5538 (2013/07/26)
A simple and efficient method for the synthesis of 2-methylquinolin-4(1H)- one derivatives using NKC-9-resin as reusable eco-friendly catalyst via Combes cyclization under solvent-free and microwave irradiation conditions is described. The quinolines were obtained in high yields and in short reaction times.
