39263-80-4

Basic information

• Product Name: 2-phenyl-1,2,4-triazaspiro[4.4]nonane-3-thione
• Synonyms: 2-phenyl-1,2,4-triazaspiro[4.4]nonane-3-thione
• CAS NO: 39263-80-4
• Molecular Formula: C₁₂H₁₅N₃S
• Molecular Weight: 233.3326
• Mol File: 39263-80-4.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-phenyl-1,2,4-triazaspiro[4.4]nonane-3-thione(CAS DataBase Reference)
• NIST Chemistry Reference: 2-phenyl-1,2,4-triazaspiro[4.4]nonane-3-thione(39263-80-4)
• EPA Substance Registry System: 2-phenyl-1,2,4-triazaspiro[4.4]nonane-3-thione(39263-80-4)

Safety Data

• Hazardous Substances Data: 39263-80-4(Hazardous Substances Data)

Upstream product

• 333-20-0 potassium thioacyanate 
• 120-92-3 cyclopentanone 
• 100-63-0 phenylhydrazine 

Relevant articles and documents

1,2,4-Triazolidine-3-thiones as narrow spectrum antibiotics against multidrug-resistant acinetobacter baumannii

With only two new classes of antibiotics developed in the last 40 years, novel antibiotics are desperately needed to combat the growing problem of multidrug-resistant and extensively drug resistant bacteria, particularly Gram-negative bacteria. Described in this letter is the synthesis and antibiotic activity of 1,2,4-triazolidine-3-thiones as narrow spectrum antibiotics. Optimization of the 1,2,4-triazolidine-3-thione scaffold identified a small molecule with potent antibiotic activity against multiple strains of multidrug-resistant and extensively drug-resistant Acinetobacter baumannii. This small molecule also shows single dose, in vivo activity in a Galleria mellonella infection model with A. baumannii and represents a promising start in the development of a class of drugs that can target this bacterial pathogen.