395-36-8

Basic information

• Product Name: N-(3-chloro-2-fluorophenyl)acetamide
• CAS NO: 395-36-8
• Molecular Formula: C₈H₇ClFNO
• Molecular Weight: 187.5987
• Mol File: 395-36-8.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 318.2°C at 760 mmHg
• Flash Point: 146.3°C
• Density: 1.352g/cm³
• Vapor Pressure: 0.000366mmHg at 25°C
• Refractive Index: 1.568
• CAS DataBase Reference: N-(3-chloro-2-fluorophenyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-chloro-2-fluorophenyl)acetamide(395-36-8)
• EPA Substance Registry System: N-(3-chloro-2-fluorophenyl)acetamide(395-36-8)

Safety Data

• Hazardous Substances Data: 395-36-8(Hazardous Substances Data)

Usage

General Description

N-(3-chloro-2-fluorophenyl)acetamide is a chemical compound with the molecular formula C8H7ClFNO. It is an amide derivative of 3-chloro-2-fluorophenylacetic acid and is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. N-(3-chloro-2-fluorophenyl)acetamide may also have potential applications in the field of organic chemistry as a building block for more complex molecules. N-(3-chloro-2-fluorophenyl)acetamide is a solid, white to off-white powder with a molecular weight of 189.6 g/mol. It is important to handle and store this chemical with proper safety precautions due to its potential reactivity and health hazards.

Upstream product

• 2106-04-9 3-chloro-2-fluoroaniline 
• 108-24-7 acetic anhydride 

Downstream Products

• 143360-05-8 N-(4-bromo-3-chloro-2-fluorophenyl)acetamide 
• 1519051-11-6 N'-(3-chloro-2-fluorophenyl)-N-phenylacetimidamide 
• 1602770-07-9 1-(4-(4-(2-methyl-4-nitrobenzo[d]thiazol-7-yloxy)phenyl)piperazin-1-yl)ethanone 
• 1602770-06-8 2-methyl-7-(4-(4-methylpiperazin-1-yl)phenoxy)-4-nitrobenzo[d]thiazole 
• 1602770-00-2 7-(4-methoxybenzylthio)-2-methyl-4-nitrobenzo[d]thiazole 
• 4146-25-2 7-chloro-2-methylbenzo[d]thiazole 
• 864271-01-2 4-isocyanato-3-fluoro-2-chlorobenzonitrile 
• 757247-99-7 4-amino-2-chloro-3-fluorobenzonitrile 

Relevant articles and documents

The fight against the influenza A virus H1N1: Synthesis, molecular modeling, and biological evaluation of benzofurazan derivatives as viral RNA polymerase inhibitors

The influenza RNA polymerase complex, which consists of the three subunits PA, PB1, and PB2, is a promising target for the development of new antiviral drugs. A large library of benzofurazan compounds was synthesized and assayed against influenza virus A/WSN/33 (H1N1). Most of the new derivatives were found to act by inhibiting the viral RNA polymerase complex through disruption of the complex formed between subunits PA and PB1. Docking studies were also performed to elucidate the binding mode of benzofurazans within the PB1 binding site in PA and to identify amino acids involved in their mechanism of action. The predicted binding pose is fully consistent with the biological data and lays the foundation for the rational development of more effective PA-PB1 inhibitors. In the fight against influenza virus A/WSN/33 (H1N1), the PA-PB1 protein-protein interaction is emerging as a new drug target. To identify small molecules able to inhibit the viral RNA polymerase complex, the benzofurazan scaffold was explored by synthesizing a large library of derivatives. Some compounds showed high anti-H1N1 activity and emerged as effective inhibitors of the PA-PB1 interaction, with IC50 values in the micromolar range. Copyright