39549-22-9

Basic information

• Product Name: 3-ethoxy-4-hydroxymandelic acid
• Synonyms: 3-ethoxy-4-hydroxymandelic acid
• CAS NO: 39549-22-9
• Molecular Formula: C₁₀H₁₂O₅
• Molecular Weight: 212.1993
• Mol File: 39549-22-9.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 425.2°Cat760mmHg
• Flash Point: 171.1°C
• Appearance: /
• Density: 1.377g/cm³
• Vapor Pressure: 5.48E-08mmHg at 25°C
• Refractive Index: 1.591
• CAS DataBase Reference: 3-ethoxy-4-hydroxymandelic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-ethoxy-4-hydroxymandelic acid(39549-22-9)
• EPA Substance Registry System: 3-ethoxy-4-hydroxymandelic acid(39549-22-9)

Safety Data

• Hazardous Substances Data: 39549-22-9(Hazardous Substances Data)

Usage

InChI:InChI=1/C10H12O5/c1-2-15-8-5-6(3-4-7(8)11)9(12)10(13)14/h3-5,9,11-12H,2H2,1H3,(H,13,14)

Upstream product

• 66644-03-9 1-(3-ethoxy-4-hydroxy-phenyl)-2,2,2-trichloro-ethanol 
• 94-71-3 2-Ethoxyphenol 
• 298-12-4 Glyoxilic acid 

Downstream Products

• 80018-50-4 [3-(ethyloxy)-4-hydroxyphenyl]acetic acid 
• 579494-69-2 acetoxy-(4-acetoxy-3-ethoxyphenyl)-acetic acid 

Relevant articles and documents

Design, synthesis, and evaluation of phenylpiperazine-phenylacetate derivatives as rapid recovery hypnotic agents

In this paper, we designed and synthesized a series of novel phenylpiperazine-phenylacetate derivatives as rapid recovery hypnotic agents. The best compound 10 had relatively high affinity for the GABAA receptor and low affinity for thirteen other off-target receptors. In three animal models (mice, rats, and rabbits), compound 10 exerted potent hypnotic effects (HD50 = 5.2 mg/kg in rabbits), comparable duration of the loss of righting reflex (LORR), and significant shorter recovery time (time to walk) than propanidid. Furthermore, compound 10 (TI = 18.1) showed higher safety profile than propanidid (TI = 14.7) in rabbits. Above results suggested that compound 10 may have predictable and rapid recovery profile in anesthesia.

Pharmaceutical compositions of short-acting sedative hypnotic agent

The invention provides pharmaceutical compositions comprising a phenylacetic acid ester compound useful for inducing or maintaining general anesthesia or sedation in mammals, methods for preparing such compositions, and methods for inducing or maintaining