395683-22-4

Basic information

• Product Name: N-n-propyl-N-[2-oxo-2-(4'-methylsulfonylphenyl)]ethyl-4-methylphenylacetamide
• Synonyms: N-n-propyl-N-[2-oxo-2-(4'-methylsulfonylphenyl)]ethyl-4-methylphenylacetamide
• CAS NO: 395683-22-4
• Molecular Weight: 387.5
• Mol File: 395683-22-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: N-n-propyl-N-[2-oxo-2-(4'-methylsulfonylphenyl)]ethyl-4-methylphenylacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-n-propyl-N-[2-oxo-2-(4'-methylsulfonylphenyl)]ethyl-4-methylphenylacetamide(395683-22-4)
• EPA Substance Registry System: N-n-propyl-N-[2-oxo-2-(4'-methylsulfonylphenyl)]ethyl-4-methylphenylacetamide(395683-22-4)

Safety Data

• Hazardous Substances Data: 395683-22-4(Hazardous Substances Data)

Upstream product

• 33155-60-1 t-butyl p-tolylacetate 
• 14062-19-2 p-tolylacetic acid ethyl ester 
• 23786-13-2 methyl p-tolylacetate 
• 35675-44-6 4-methylphenylacetyl chloride 
• 54009-36-8 2-amino-1-(4-(methylsulfonyl)phenyl)ethanone 
• 22535-04-2 p-methylphenylacetyl bromide 
• 657419-48-2 N-n-propyl-N-[2-hydroxy-2-(4'-methylsulfonylphenyl)]ethyl-4-methylphenylacetamide 
• 479679-98-6 N-n-propyl-β-hydroxy-4-methylsulfonylphenylethanamine 
• 93114-06-8 (4-methanesulfonyl-phenyl)-oxirane 

Downstream Products

• 395683-14-4 Imrecoxib 

Relevant articles and documents

Preparation method of imrecoxib

The invention provides a preparation method of imrecoxib. The preparation method of the imrecoxib comprises the steps that alpha-n-propylamino-4-methyl sulfonate acetophenone (II) and 4-methyl phenylacetate (III) are used as main raw materials, amidation

Preparation methods of imrecoxib intermediate and imrecoxib

The invention discloses preparation methods of an imrecoxib intermediate and imrecoxib. The preparation method of N-propyl-N-[2-oxo-2-(4-mesylphenyl)]ethyl-4-methyl phenyl acetamide as the imrecoxib intermediate comprises the following steps of performing substitution reaction on 2-amino-1-p-methylsulfonyl acetophenone and 1-halopropane in a system of an acid binding agent and a solvent to obtain2-propylamino-1-p-methylsulfonyl acetophenone; and enabling 2-propylamino-1-p-methylsulfonyl acetophenone and p-methyl phenylacetyl halide to perform amidation in the system of the acid binding agentand the solvent to obtain N-propyl-N-[2-oxo-2-(4-mesylphenyl)] ethyl-4-methyl phenyl acetamide. The preparation method of the imrecoxib comprises the following step of performing condensation and cyclization reaction on N-propyl-N-[2-oxo-2-(4-mesylphenyl)] ethyl-4-methyl phenyl acetamide in a system of an alkaline matter and a solvent on the basis. The synthetic route provided by the invention enables the reaction process to be more simple and post-treatment separation to be easier and is capable of acquiring ideal yield.