39743-20-9

Basic information

• Product Name: 1-(3-CHLOROPROPYL)-PYRROLIDINE
• Synonyms: N-CHLOROPROPYL PYRROLIDINE;Albb-007086;(3-Chloropropyl)pyrrolidine, HCl;Pyrrolidine,1-(3-chloropropyl)-;1-(3-CHLOROPROPYL)-PYRROLIDINE
• CAS NO: 39743-20-9
• Molecular Formula: C₇H₁₄ClN
• Molecular Weight: 147.65
• Mol File: 39743-20-9.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 194.5 °C at 760 mmHg
• Flash Point: 71.4 °C
• Appearance: /
• Density: 1.016 g/cm³
• Vapor Pressure: 0.44mmHg at 25°C
• Refractive Index: 1.474
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C
• PKA: 10.10±0.20(Predicted)
• CAS DataBase Reference: 1-(3-CHLOROPROPYL)-PYRROLIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-CHLOROPROPYL)-PYRROLIDINE(39743-20-9)
• EPA Substance Registry System: 1-(3-CHLOROPROPYL)-PYRROLIDINE(39743-20-9)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 39743-20-9(Hazardous Substances Data)

Usage

General Description

1-(3-chloropropyl)-pyrrolidine is a chemical compound with the molecular formula C8H15ClN. It is a colorless liquid with a molecular weight of 155.66 g/mol. This chemical is used in organic synthesis and pharmaceutical research as a building block for the synthesis of various organic compounds and pharmaceuticals. Its main applications include the production of pharmaceutical intermediates, agrochemicals, and organic synthesis. It is classified as a hazardous chemical and should be handled with caution in a controlled laboratory environment.

InChI:InChI=1/C7H14ClN/c8-4-3-7-9-5-1-2-6-9/h1-7H2

Upstream product

• 123-75-1 pyrrolidine 
• 109-70-6 1.3-chlorobromopropane 
• 19748-66-4 3-pyrrolidin-1-yl-propan-1-ol 
• 57616-69-0 1-(3-chloropropyl)pyrrolidine hydrochloride 

Downstream Products

• 3733-37-7 10-(3-pyrrolidin-1-yl-propyl)-10H-phenothiazine 
• 3810-87-5 2-chloro-10-(3-pyrrolidin-1-yl-propyl)-10H-phenothiazine 
• 112972-12-0 2,2-diphenyl-5-pyrrolidino-valeronitrile; hydrochloride 
• 36978-99-1 2-methoxy-10-(3-pyrrolidino-propyl)-phenothiazine 
• 102021-80-7 3,4,5-trimethoxy-trans-cinnamic acid-(3-pyrrolidino-propyl ester) 
• 76277-39-9 2-(3-pyrrolidinylpropyl)-1H-isoindole-1,3(2H)-dione 
• 101085-07-8 2-(3-pyrrolidino-propylamino)-ethanol 
• 109260-72-2 1-[3-(2-chloro-phenothiazin-10-yl)-propyl]-4-(3-pyrrolidino-propyl)-piperazine 
• 94037-20-4 9-(3-Pyrrolidin-1-yl-propyl)-9H-10-thia-2,9-diaza-anthracene 
• 115072-04-3 10-(3-Pyrrolidin-1-yl-propyl)-10H-9-thia-2,10-diaza-anthracene; compound with oxalic acid 
• 115072-14-5 C₁₉H₂₄N₃S⁽¹⁺⁾*C₂HO₄^(1-)*HI 
• 359701-48-7 4-(2-bromo-4-fluorophenoxy)-6-methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinazoline 
• 958264-04-5 8-chloro-10-(4-dimethylaminophenyl)-3-(3-pyrrolidin-1-ylpropyl)-10H-benzo[g]pteridine-2,4-dione 
• 958264-07-8 8-chloro-10-(4-piperidin-1-yl-phenyl)-3-(3-pyrrolidin-1-ylpropyl)-10H-benzo[g]pteridine-2,4-dione 

Relevant articles and documents

Multifunctional cholinesterase inhibitors for Alzheimer's disease: Synthesis, biological evaluations, and docking studies of o/p-propoxyphenylsubstituted-1H-benzimidazole derivatives

This study indicates the synthesis, cholinesterase (ChE) inhibitory activity, and molecular modeling studies of 48 compounds as o- and p-(3-substitutedethoxyphenyl)-1H-benzimidazole derivatives. According to the ChE inhibitor activity results, generally, para series are more active against acetylcholinesterase (AChE) whereas ortho series are more active against butyrylcholinesterase (BuChE). The most active compounds against AChE and BuChE are compounds A12 and B14 with IC50 values of 0.14 and 0.22 μM, respectively. Additionally, the most active 16 compounds against AChE/BuChE were chosen to investigate the neuroprotective effects, and the results indicated that most of the compounds have free radical scavenging properties and show their effects by reducing free radical production; moreover, some of the compounds significantly increased the viability of SH-SY5Y cells exposed to H2O2. Overall, compounds A12 and B14 with potential AChE and BuChE inhibitory activities, high neuroprotection against H2O2-induced toxicity, free radical scavenging properties, and metal chelating abilities may be considered as lead molecules for the development of multi-target-directed ligands against Alzheimer's disease.

Carboline- and phenothiazine-derivated heterocycles as potent SIGMA-1 protein ligands

Sigma 1 receptors are associated with neurodegenerative and psychiatric disorders. These receptors, via their chaperoning functions that counteract endoplasmic reticulum stress and block neurodegeneration, may serve as a target for a new generation of antidepressants or neuroprotective agents. The involvement of these receptors has also been observed in neuropathic pain and cancer. Only a few ligands, such as Igmesine and Anavex 2-73, have been involved in clinical trials. Thus the development of sigma 1 ligands is of interest to a new generation of drugs. Previous work in our lab underlined the potency of benzannulated bicyclic compounds as interesting ligands. Herein the work was extended to a series of novel tricyclic compounds. Carboline- and phenothiazine-derivated compounds were designed and synthesized. In vitro competition binding assays for sigma 1 and 2 receptors showed that most of them have high affinity for sigma 1 receptor (Ki = 2.5-18 nM), and selectivity toward sigma 2 receptor, without cytotoxic effects on SY5Y cells.

NOVEL CYCLOSPORIN DERIVATIVES AND USES THEREOF

The present invention relates to a compound of the Formula (I)): or pharmaceutically acceptable salt thereof, wherein the symbols are as defined in the specification; a pharmaceutical composition comprising the same, a method for treating or preventing viral infections, inflammation, dry eye, central nervous disorders, cardiovascular diseases, cancer, obesity, diabetes, muscular dystrophy, and hair loss.