398487-42-8

Basic information

• Product Name: 4-chloro-6-cyano-7-(3-(pyrrolidin-1-yl)propoxy)quinoline
• Synonyms: 4-chloro-6-cyano-7-(3-(pyrrolidin-1-yl)propoxy)quinoline
• CAS NO: 398487-42-8
• Molecular Weight: 315.802
• Mol File: 398487-42-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-chloro-6-cyano-7-(3-(pyrrolidin-1-yl)propoxy)quinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 4-chloro-6-cyano-7-(3-(pyrrolidin-1-yl)propoxy)quinoline(398487-42-8)
• EPA Substance Registry System: 4-chloro-6-cyano-7-(3-(pyrrolidin-1-yl)propoxy)quinoline(398487-42-8)

Safety Data

• Hazardous Substances Data: 398487-42-8(Hazardous Substances Data)

Upstream product

• 19748-66-4 3-pyrrolidin-1-yl-propan-1-ol 
• 352205-91-5 4-chloro-6-cyano-7-hydroxyquinoline 
• 1972-28-7 diethylazodicarboxylate 

Relevant articles and documents

Quinoline derivatives having vegf inhibiting activity

The invention relates to compounds of formula (I) wherein: either any one of G1, G2, G3, G4 and G5 is nitrogen and the other four are —CH—, or G1, G2, G3, G4 and G5 are all —CH—; Z is —O—, —NH—, —S—, —CH2— or a direct bond; Z is linked to any one of G1, G2, G3 and G4; n is an integer from 0 to 5; m is an integer from 0 to 3; Ra represents hydrogen or fluoro; Rb, R1 and R2 are defined herein and salt thereof, process for the preparation so such compounds, pharmaceutical compositions containing a compound of formula I or a pharmaceutically acceptable salt thereof as active ingredient and the use of a compound of formula I in the manufacture of a medicament for the production of an antiangiogenic and/or vascular permeability reducing effect in warm-blodded animals. The compounds of formula I and the pharmaceutically acceptable salts thereof inhibit the effects of VEGF, a property of value in the treatment of a number of diseases states including cancer and rheumatoid arthritis.