3988-76-9

Basic information

• Product Name: (2E)-1,3-di(2-furyl)prop-2-en-1-one
• Synonyms: 1,3-di(furan-2-yl)prop-2-en-1-one
• CAS NO: 3988-76-9
• Molecular Formula: C₁₁H₈O₃
• Molecular Weight: 188.1794
• Mol File: 3988-76-9.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 294.2°C at 760 mmHg
• Flash Point: 133.7°C
• Density: 1.21g/cm³
• Vapor Pressure: 0.00165mmHg at 25°C
• Refractive Index: 1.579
• CAS DataBase Reference: (2E)-1,3-di(2-furyl)prop-2-en-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: (2E)-1,3-di(2-furyl)prop-2-en-1-one(3988-76-9)
• EPA Substance Registry System: (2E)-1,3-di(2-furyl)prop-2-en-1-one(3988-76-9)

Safety Data

• Hazardous Substances Data: 3988-76-9(Hazardous Substances Data)

Usage

General Description

(2E)-1,3-di(2-furyl)prop-2-en-1-one is a chemical compound with the molecular formula C10H8O3. It is a yellow crystalline solid with a furan-2-yl and enone functional group. (2E)-1,3-di(2-furyl)prop-2-en-1-one is commonly used as a flavoring agent in the food industry due to its sweet, caramel-like aroma. It is also utilized in the production of perfumes and fragrances. Additionally, (2E)-1,3-di(2-furyl)prop-2-en-1-one has been studied for its potential pharmacological properties, including its anti-inflammatory and anti-oxidant effects. However, further research is needed to fully understand its biological activities and potential applications in medicine.

Upstream product

• 98-01-1 furfural 
• 1192-62-7 1-(2-furyl)-1-ethanone 

Downstream Products

• 52395-51-4 4-(1,3-di-furan-2-yl-3-oxo-propyl)-1,2-diphenyl-pyrazolidine-3,5-dione 
• 1024195-36-5 ethyl 4,6-bis(furan-2-yl)-2-oxocyclohex-3-ene-1-carboxylate 
• 3878-19-1 fuberidazole 
• 98677-49-7 3,5-di-furan-2-yl-4,5-dihydro-pyrazole-1-carbothioic acid anilide 
• 791828-03-0 1-(N-allylthiocarbamoyl)-3,5-di(2-furyl)-2-pyrazoline 
• 1028209-04-2 ethyl 3-amino-4,6-di-(2-furyl)thieno[2,3-b]pyridine-2-carboxylate 
• 1028209-00-8 4,6-di(furan-2-yl)-2-thioxo-1,2-dihydropyridine-3-carbonitrile 
• 16753-13-2 3,5-di(furan-2-yl)-1-phenyl-4,5-dihydro-1H-pyrazole 
• 936011-81-3 3,5-di(furan-2-yl)-4,5-dihydro-1H-pyrazole-1-carbothioamide 
• 222538-69-4 3-amino-2-[(3,5-difurylpyrazolin-1-yl)carbonyl]-4,6-dimethylthieno[2,3-b]pyridine 

Relevant articles and documents

Bi(OTf)3 catalyzed disproportionation reaction of cinnamyl alcohols

Bi(OTf)3 catalyzed disproportionation reaction of cinnamyl alcohols provides chalcones and benzyl styrenes. The use of various metal triflates is investigated herein for facile and efficient redox transformation. A plausible mechanism has been proposed.

Aluminum chloride-catalyzed C-alkylation of pyrrole and indole with chalcone and bis-chalcone derivatives

The AlCl3-catalyzed alkylation of pyrrole (2) with chalcone (1a-i) at a ratio of 8:1 in the presence of 10 mol% AlCl3 gave the solely 2-alkyl pyrroles (3a-i) at room temperature for 12 in good yields. The same reaction was performed with pyrrole (2) and chalcone at a ratio of 1:3 in CH3CN at rt for 3 h to achieve 2,5-dialkyl pyrroles (4a-f). In addition, the reaction of the pyrrole (2) and indole (7) on 1,4-phenylene bis-chalcones (5a-g) at the ratio of 8:1 at rt for 24 h gave the double-addition products 6a-g and 8a-g in good yields, respectively. The structure of the products was confirmed by 1H and 13C NMR spectroscopy and elemental analysis.

Synthesis, cyclooxygenase inhibition, anti-inflammatory evaluation, and ulcerogenic liability of new 1,3,5-triarylpyrazoline derivatives possessing a methanesulfonyl pharmacophore

A new series of 1,3,5-triarylpyrazolines 13a–l was synthesized and all prepared compounds were evaluated for their in vitro COX-1/COX-2 inhibitory activity and in vivo anti-inflammatory activity. All test compounds were more selective for the COX-2 isozyme and showed good in vivo anti-inflammatory activity. Compound 13h was the most COX-2 selective compound (COX-2 selectivity index (SI)=10.23) and the most potent anti-inflammatory derivative (ED50-60.1μmol/kg) in comparison with celecoxib (COX-2 SI=9.29 and ED50=81.4μmol/kg). All screened compounds were less ulcerogenic (ulcer indexes (UI)=0.33–1.33) than aspirin (UI=2.33) and comparable to celecoxib (UI=0.33).