399-00-8

Basic information

• Product Name: 5-BROMO-4-FLUORO-2-HYDROXY-BENZALDEHYDE
• Synonyms: 5-BROMO-4-FLUORO-2-HYDROXY-BENZALDEHYDE;4-Fluoro-5-bromo-2-hydroxybenzaldehyde
• CAS NO: 399-00-8
• Molecular Formula: C₇H₄BrFO₂
• Molecular Weight: 219.01
• Mol File: 399-00-8.mol
• Article Data: 9

Chemical Properties

• Melting Point: 81 °C
• Boiling Point: 256.6 °C at 760 mmHg
• Flash Point: 109 °C
• Appearance: /
• Density: 1.826 g/cm³
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 6.62±0.23(Predicted)
• CAS DataBase Reference: 5-BROMO-4-FLUORO-2-HYDROXY-BENZALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BROMO-4-FLUORO-2-HYDROXY-BENZALDEHYDE(399-00-8)
• EPA Substance Registry System: 5-BROMO-4-FLUORO-2-HYDROXY-BENZALDEHYDE(399-00-8)

Safety Data

• Hazardous Substances Data: 399-00-8(Hazardous Substances Data)

Usage

General Description

5-Bromo-4-Fluoro-2-Hydroxy-Benzaldehyde is a chemical compound that is predominantly used in the pharmaceutical and chemical manufacturing industries due to its unique properties. Its molecular formula is C7H4BrFO2, and it's a halogenoaldehyde with various applications in organic synthesis. 5-BROMO-4-FLUORO-2-HYDROXY-BENZALDEHYDE is classified as a bromo-, fluoro- and hydroxy-substituted benzaldehyde meaning it contains bromine, fluorine, and a hydroxy group attached to a benzene ring. It exhibits a molar mass of around 235.01 g/mol. The compound may be utilized in the construction of various other complex organic molecules due to its intermediate reactivity. However, like many chemicals, it should be handled with caution as it has the potential to cause skin and eye irritation, and it may also cause respiratory issues if inhaled directly.

Upstream product

• 67-66-3 chloroform 
• 372-20-3 3-fluorophenol 
• 7726-95-6 bromine 
• 77771-02-9 3-bromo-4-fluorobenzaldehyde 
• 348-28-7 4-fluoro-2-hydroxybenzaldehyde 

Downstream Products

• 361-44-4 5-bromo-4-fluoro-2-hydroxy-3-nitro-benzaldehyde 

Relevant articles and documents

Structure-Based Design of Potent and Orally Active Isoindolinone Inhibitors of MDM2-p53 Protein-Protein Interaction

Inhibition of murine double minute 2 (MDM2)-p53 protein-protein interaction with small molecules has been shown to reactivate p53 and inhibit tumor growth. Here, we describe rational, structure-guided, design of novel isoindolinone-based MDM2 inhibitors. MDM2 X-ray crystallography, quantum mechanics ligand-based design, and metabolite identification all contributed toward the discovery of potent in vitro and in vivo inhibitors of the MDM2-p53 interaction with representative compounds inducing cytostasis in an SJSA-1 osteosarcoma xenograft model following once-daily oral administration.

Pd-Catalyzed Ortho C-H Hydroxylation of Benzaldehydes Using a Transient Directing Group

The direct Pd-catalyzed ortho C-H hydroxylation of benzaldehydes was achieved using 4-chloroanthranilic acid as the transient directing group, 1-fluoro-2,4,6-trimethylpyridnium triflate as the bystanding oxidant, and p-toluenesulfonic acid as the putative oxygen nucleophile. The unusual C-H chlorination and polyfluoroalkoxylation reactions signaled the importance of external nucleophiles to the outcome of Pd(IV) reductive eliminations.

CONDENSED TRICLYCLIC COMPOUNDS AS INHIBITORS OF HIV REPLICATION

Compounds of formula (I) and pharmaceutical compositions thereof: wherein A1 A2 and A3 are each independently selected from the group consisting of N and CR3, wherein R1 is an optionally substituted heterocyclyl or an optionally substituted -(C1-6)alkyl-heterocyclyl, R2 is an optionally substituted aryl or an optionally subsisted heteroaryl, R4 is an optionally substituted aryl, an optionally substituted heterocyclyl or an optionally substituted heteroaryl, useful as an inbitor of HIV replication.