39989-39-4

Basic information

• Product Name: 7-METHOXY-ISOQUINOLINE
• Synonyms: 7-METHOXY-ISOQUINOLINE;7-Methoxyisoquinoline 96%;7-Methoxy-2-azanaphthalene;Isoquinoline, 7-methoxy-
• CAS NO: 39989-39-4
• Molecular Formula: C₁₀H₉NO
• Molecular Weight: 159.18456
• EINECS: -0
• Product Categories: blocks;Heterocycles;Quinolines;Quinoline&Isoquinoline
• Mol File: 39989-39-4.mol
• Article Data: 15

Chemical Properties

• Melting Point: 49°C
• Boiling Point: 284.68°C (rough estimate)
• Flash Point: 108.428 °C
• Appearance: /
• Density: 1.1202 (rough estimate)
• Vapor Pressure: 0.003mmHg at 25°C
• Refractive Index: 1.6070 (estimate)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 5.54±0.10(Predicted)
• CAS DataBase Reference: 7-METHOXY-ISOQUINOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 7-METHOXY-ISOQUINOLINE(39989-39-4)
• EPA Substance Registry System: 7-METHOXY-ISOQUINOLINE(39989-39-4)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22
• Hazardous Substances Data: 39989-39-4(Hazardous Substances Data)

Usage

General Description

7-Methoxy-isoquinoline is a chemical compound with the molecular formula C10H9NO2. It is a derivative of isoquinoline, a heterocyclic aromatic organic compound. This chemical is known for its potential pharmacological activities, including anti-inflammatory and antibacterial properties. It has also been studied for its potential to be used as a precursor in the synthesis of various pharmaceuticals and natural products. Additionally, 7-Methoxy-isoquinoline is being researched for its potential applications in the development of new drugs and therapeutic agents. Its structural and pharmacological properties make it a valuable compound in the pharmaceutical and chemical industries.

InChI:InChI=1/C10H9NO/c1-12-10-3-2-8-4-5-11-7-9(8)6-10/h2-7H,1H3

Upstream product

• 645-36-3 2,2-diethoxy-ethanamine 
• 591-31-1 3-methoxy-benzaldehyde 
• 22483-09-6 2,2-dimethoxyethylamine 
• 407-25-0 trifluoroacetic anhydride 
• 3469-07-6 5-methoxy-1H-indene 
• 3469-09-8 6-methoxyindan-1-ol 
• 13623-25-1 6-methoxy-2,3-dihydro-1H-inden-1-one 
• 120347-56-0 N-(3-methoxybenzylidene)-t-butylamine 
• 61190-04-3 (2,2-Diethoxy-ethyl)-[1-(3-methoxy-phenyl)-meth-(Z)-ylidene]-amine 
• 39964-84-6 (2,2-Dimethoxy-ethyl)-[1-(3-methoxy-phenyl)-meth-(Z)-ylidene]-amine 
• 84900-37-8 2,4,6-Trimethyl-benzenesulfonate2-amino-7-methoxy-isoquinolinium; 
• 61190-11-2 2,2-diethoxy-N-(3-methoxybenzyl)ethanamine 
• 39964-88-0 N-(3-methoxybenzyl)-N-tosylaminoacetaldehyde dimethyl acetal 
• 90908-99-9 (3-methoxy)-benzyliminoacetal 

Downstream Products

• 53366-09-9 N-methyl-7-methoxyisoquinolinium iodide 
• 43207-78-9 7-methoxy-1,2,3,4-tetrahydroisoquinoline 
• 146607-34-3 7-methoxyisoquinoline 2-oxide 
• 63485-75-6 7-methoxy-8-nitro-isoquinoline 
• 54893-23-1 7-methoxy-N-methyl-1,2,3,4-tetrahydroisoquinoline 
• 1338322-22-7 (S)-phenyl 7-methoxy-1-((S)-2-(4-methoxyphenyl)-4-methyl-5-oxo-4,5-dihydrooxazol-4-yl)-isoquinoline-2(1H)-carboxylate 
• 16027-16-0 7-methoxy-2H-isoquinolin-1-one 
• 952569-54-9 1-iodo-7-methoxyisoquinoline 
• 7651-83-4 isoquinolin-7-ol 
• 16027-16-0 7-Methoxy-isocarbostyril 
• 832088-74-1 benzyl 7-[4-ethoxycarbonyl-1-(pyridin-4-yl)piperidin-4-ylmethoxy]-1,2,3,4-tetrahydroisoquinolin-2-carboxylate 
• 247132-98-5 benzyl 4-(2-tert-butoxycarbonyl-1,2,3,4-tetrahydroisoquinolin-7-yloxymethyl)piperidin-1-carboxylate 

Relevant articles and documents

Synthesis of Indole-Dihydroisoquinoline Sulfonyl Ureas via Three-Component Reactions

Isoquinolines activated with sulfamoyl chlorides were reacted with indoles in a 3-component reaction to generate a library of dihydroisoquinoline derivatives. Using a differential protecting group strategy, products could be further derivatised. Synthesis of isoquinoline starting materials using several different methods is also described.

Discovery of novel tetrahydroisoquinoline derivatives as potent and selective factor Xa inhibitors

A series of novel 2,7-disubstituted tetrahydroisoquinoline derivatives were designed and synthesized. Among these derivatives, compounds 1 and 2 (JTV-803) exhibited potent inhibitory activity against FXa and good selectivity with respect to other serine proteases (thrombin, plasmin, and trypsin). In addition, compound 2 exhibited potent anti-FXa activity after intravenous and oral administration to cynomolgus monkey, and showed a dose-dependent antithrombotic effect in a rat model of venous thrombosis.

Compounds as delta opioid agonists

Compounds of the formula (I)—shown below—are described. The compounds are useful in the manufacture of a pharmaceutical composition for preventing or treating inflammatory diseases such as arthritis, psoriasis, asthma, or inflammatory bowel disease, disorders of respiratory function, gastrointestinal disorders such as functional bowel disease, functional GI disorders such as irritable bowel syndrome, functional diarrhoea, functional distension, functional pain, non-ulcerogenic dyspepsia or others associated with disorders of motility or secretion, urogenital tract disorders such as incontinence, as analgesics for treating pain including non-somatic pain, or as immunosuppressants to prevent rejection in organ transplant and skin graft.