40054-08-8Relevant articles and documents
Diastereoselective conjugate 1,6-addition of lithium amides to naphthyloxazolines. Mechanistic studies and synthesis of δ-amino acid derivatives
Shimano, Masanao,Matsuo, Atsushi
, p. 4787 - 4810 (1998)
The novel 1,6-amino addition reaction to the naphthalene ring system followed by the electrophilic alkylation is presented. The detailed mechanistic studies suggest the existence of two equilibrations that result in the 1,4-amino addition reaction and the 1,6-amino addition reaction. The stability and bulkiness of lithium amide play a key role in directing the course of the reaction. The transformation of the 1,6-amino adducts to other useful compounds is concisely demonstrated. The methodology provides a remote-controlled diastereoselective synthesis of δ-amino acid derivatives.
Oxazolinyl-Assisted Ru(II)-Catalyzed C?H Functionalization Based on Carbene Migratory Insertion: A One-Pot Three-Component Cascade Cyclization
Kumar, Gangam Srikanth,Khot, Nandkishor Prakash,Kapur, Manmohan
supporting information, p. 73 - 78 (2018/12/11)
A rare, ruthenium-catalyzed, oxazolinlyl assisted C?H functionalization and three-component cascade cyclization for the synthesis of isoquinolinones via a metal-carbene migratory insertion is reported. The transformation is unique since it involves the fo
A general and efficient palladium-catalyzed carbonylative synthesis of 2-aryloxazolines and 2-aryloxazines from aryl bromides
Wu, Xiao-Feng,Neumann, Helfried,Neumann, Stephan,Beller, Matthias
, p. 13619 - 13623 (2013/01/15)
Oxazoline is OK! A general and efficient method for the synthesis of oxazolines has been developed (see scheme). This allowed the preparation of 27 five-membered-ring heterocycles and 11 six-membered-ring heterocycles in moderate to good yields. Copyright
