40054-69-1

Basic information

• Product Name: ETIZOLAM
• Synonyms: 4-c)thieno(2,3-e)(1,4)-diazepine,6-(o-chlorophenyl)-8-ethyl-1-4h-s-triazolo(;6-(o-chlorophenyl)-8-ethyl-1-methyl-4h-s-triazolo(3,4-c)thieno(2,3-e)(1,4)-d;6-(o-chlorphenyl)-8-aethyl-1-methyl-4h-s-triazolo(3,4-c)thieno(2,3-e)(1,4)di;6h-thieno(3,2-f)(1,2,4)triazolo(4,3-a)(1,4)diazepine,4-(2-chlorophenyl)-2-et;8-ethyl-6-(o-chlorophenyl)-1-methyl-4h-s-triazolo(3,4c)thieno(2,3e)-1,4-diaz;ahr3219;azepin;depas
• CAS NO: 40054-69-1
• Molecular Formula: C₁₇H₁₅ClN₄S
• Molecular Weight: 342.85
• EINECS: 1592732-453-0
• Product Categories: Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds;Inhibitors;pharmaceutical intermediate;pharmaceutical intermediate and medicine grade
• Mol File: 40054-69-1.mol
• Article Data: 1

Chemical Properties

• Melting Point: 147-148℃
• Boiling Point: 264.5°C (rough estimate)
• Flash Point: 283.6 °C
• Appearance: /
• Density: 1.43
• Vapor Pressure: 6.02E-12mmHg at 25°C
• Refractive Index: 1.6100 (estimate)
• Storage Temp.: ?20°C
• PKA: 2.37±0.40(Predicted)
• CAS DataBase Reference: ETIZOLAM(CAS DataBase Reference)
• NIST Chemistry Reference: ETIZOLAM(40054-69-1)
• EPA Substance Registry System: ETIZOLAM(40054-69-1)

Safety Data

• Hazard Codes: F,T
• Statements: 11-23/24/25-39/23/24/25
• Safety Statements: 7-16-36/37-45
• RIDADR: UN1230 - class 3 - PG 2 - Methanol, solution
• WGK Germany: 1
• Hazardous Substances Data: 40054-69-1(Hazardous Substances Data)

Usage

Description

Different sources of media describe the Description of 40054-69-1 differently. You can refer to the following data:
1. Etizolam is a benzodiazepine analog used for the short-term treatment of insomnia, anxiety or panic attacks. It has amnesic, anxiolytic, anticonvulsant, and hypnotic, sedative and skeletal muscle relaxant properties. It acts on the benzodiazepine site of the GABA-A receptor as an agonist to increase inhibitory GABAergic transmission throughout the central nervous system.
2. Etizolam is a potent thienodiazepine anxiolytic closely related to brotizolam. Pharmacologically, however, its profile most resembles that of diazepam.

References

https://www.drugbank.ca/drugs/DB09166 https://en.wikipedia.org/wiki/Etizolam Casacchia, Massimo, F. Bolino, and U. Ecari. "Etizolam in the treatment of generalized anxiety disorder: a double-blind study versus placebo."Current Medical Research & Opinion 12.4(2008):215-223. Savoldi, F, G. Somenzini, and U. Ecari. "Etizolam versus placebo in the treatment of panic disorder with agoraphobia: a double-blind study."Current Medical Research & Opinion 12.3(1990):185. Hirashima, Y, et al. "Etizolam, an anti-anxiety agent, attenuates recurrence of chronic subdural hematoma--evaluation by computed tomography." Neurologia medico-chirurgica 42.2(2002):53-55.

Originator

Yoshitomi (Japan)

Uses

Different sources of media describe the Uses of 40054-69-1 differently. You can refer to the following data:
1. Etilozam is a a thienodiazepine benzodiazepine derivative, and has amnesic, anxiolytic, anticonvulsant, hypnotic, sedative and skeletal muscle relaxant properties. Etizolam is an anxiolytic related to that of the classic benzodiazepines. Etizolam has effect on monoamine metabolism in brain. Etilozam can be used for the short-term treatment of insomnia, anxiety or panic attacks.
2. Nasal Dilator

Brand name

DEPAS

InChI:InChI=1/C17H15ClN4S/c1-3-11-8-13-16(12-6-4-5-7-14(12)18)19-9-15-21-20-10(2)22(15)17(13)23-11/h4-8H,3,9H2,1-2H3

Upstream product

• 33671-37-3 5-(2-Chlorophenyl)-7-ethyl-1,3-dihydro-2H-thieno[2,3-e]1,4-diazepin-2-one 
• 40054-40-8 5-(2-chlorophenyl)-7-ethyl-1,3-dihydro-2H-thieno[2,3-e]-1,4-diazepin-2-thione 
• 108-24-7 acetic anhydride 
• 40054-43-1 5-(2-chloro-phenyl)-7-ethyl-1,3-dihydro-thieno[2,3-e][1,4]diazepin-2-one hydrazone 
• 62551-51-3 4-(2-chloro-phenyl)-2-ethyl-9-methyl-5,6-dihydro-4H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine 

Downstream Products

• 140632-75-3 [2-(3-Aminomethyl-5-methyl-[1,2,4]triazol-4-yl)-5-ethyl-thiophen-3-yl]-(2-chloro-phenyl)-methanol 
• 69298-45-9 3-aminomethyl-4-<3-(o-chlorobenzoyl)-5-ethylthiophen-2-yl>-5-methyl-4H-1,2,4-triazole hydrochloride 
• 140484-63-5 3-aminomethyl-4-(3-(2-chlorobenzoyl)-5-ethylthiophen-2-yl)-5-methyl[1,2,4]triazole 
• 54905-10-1 1-[4-(2-chloro-phenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-2-yl]-ethanone 

Relevant articles and documents

Syntheses and structure-activity relationships of 6-Aryl-4H-s-triazolo[3,4-c]thieno[2,3-e][1,4]diazepines

A variety of 6 aryl 4H s triazolo [3,4-c]thieno [2,3-e] [1,4]diazepines was synthesized and tested for anti-pentylenetetrazole activity and inhibition of fighting episodes. The structure-activity relationships are discussed. Some compounds were more active than diazepam in the two assays. Among them, 6 (o chlorophenyl) 8 ethyl 1 methyl 4H s triazolo [3,4-c] thieno [2,3-e][1,4] diazepine was found to have favourable properties as an anxiolytic drug with very low toxicity. Clinical studies of this compound (Y-7131) are under way.