400652-46-2

Basic information

• Product Name: (S)-benzyl 1-aMinopropan-2-ylcarbaMate
• Synonyms: (S)-benzyl 1-aMinopropan-2-ylcarbaMate;[(1S)-2-Amino-1-methylethyl]carbamic acid phenylmethyl ester;N-[(1S)-2-Amino-1-methylethyl]carbamic acid phenylmethyl ester;(S)-2-N-Cbz-propane-1,2-diaMine;Carbamic acid, N-[(1S)-2-amino-1-methylethyl]-, phenylmethyl ester
• CAS NO: 400652-46-2
• Molecular Formula: C₁₁H₁₆N₂O₂
• Molecular Weight: 208.25694
• Mol File: 400652-46-2.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Density: 1.107
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: (S)-benzyl 1-aMinopropan-2-ylcarbaMate(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-benzyl 1-aMinopropan-2-ylcarbaMate(400652-46-2)
• EPA Substance Registry System: (S)-benzyl 1-aMinopropan-2-ylcarbaMate(400652-46-2)

Safety Data

• Hazardous Substances Data: 400652-46-2(Hazardous Substances Data)

Usage

General Description

S-benzyl 1-aminopropan-2-ylcarbamate, also known as S-Ethylisothiourea, is a chemical compound used in the pharmaceutical industry as a potential antidote to cyanide poisoning. It works by binding to and neutralizing the toxic effects of cyanide in the body. It is a carbamate derivative and an isothiourea compound, and its chemical structure consists of a benzyl group connected to a 1-aminopropan-2-ylcarbamate group. Studies have shown that this compound has the potential to protect against cyanide poisoning and could be an important tool in the treatment of cyanide exposure.

Upstream product

• 15967-72-3 (S)-1,2-diaminopropane 
• 28170-07-2 benzyl phenyl carbonate 
• 13139-27-0 L-α-N-Cbz-alaninamide 
• 17343-54-3 (S)-2-(benzyloxycarbonylamino)-propionitrile 
• 6429-44-3 (S)-(-)-N-(benzyloxycarbonyl)alaninol 
• 190393-64-7 (S)-2-[(benzyloxycarbonyl)amino]propan-1-yl azide 

Downstream Products

• 868670-30-8 1-(2-benzyloxycarbonylamino-propyl)-5-ethyl-2-propyl-1H-pyrrole-3-carboxylic acid methyl ester 
• 1172596-74-5 benzyl (S)-1-isothiocyanatopropan-2-ylcarbamate 
• 400652-51-9 C₁₆H₂₄N₂O₄ 

Relevant articles and documents

PANTOTHENAMIDE ANALOGUES

The present invention provides compounds that have antimalarial activity. More in particular, the present invention provides novel compounds that are analogues of pantothenamides. The pantothenamide analogues of this invention have particularly low ICsub

Parallel synthesis of an oligomeric imidazole-4, 5-dicarboxamide library

A library of oligomeric compounds was synthesized based on the imidazole-4, 5-dicarboxylic acid scaffold along with amino acid esters and chiral diamines derived from amino acids. The final compounds incorporate nonpolar amino acids (Leu, Phe, Trp), polar amino acids (Ser, Asp, Arg), and neutral amino acids (Gly, Ala), and were designed to be useful in screening for inhibitors of protein-protein interactions. Many of the protected and deprotected oligomers show evidence of conformational isomers persistent at room temperature in aqueous solution. A total of 317 final oligomers, out of 441 targeted compounds, were obtained in high analytical purity and of sufficient quantity to submit them for high-throughput screening as part of the NIH Roadmap.

A simple approach for the synthesis of new classes of dithiocarbamate-linked peptidomimetics

An efficient protocol for the synthesis of a new series of dithiocarbamate-linked peptidomimetics is described. The in situ generated dithiocarbamic acid intermediate formed by the reaction of an amino acid ester and carbon disulfide in the presence of triethylamine was treated with N-protected amino alkyl iodide to afford title compounds 3a-g in good to moderate yields. The synthesis of N-Fmoc-protected tripeptidomimetics 4a-e containing two dithiocarbamate linkages is also described. The protocol was further extended to synthesize N,N′-orthogonally protected dithiocarbamate-linked dipeptidomimetics 7a-c as well. The mild reaction conditions and non-toxic reagents are the advantages of the present method.