400882-07-7 Usage
Chemical Properties
Cyflumetofen is an acracide and insecticide. It has a low aqueous solubility and is non-toxic. It tends not to be persistent in the environment. Whilst its toxicity to honeybees is low it t has a moderate to high toxicity to most other biodiversity. Its oral mammalian toxicity is low.
Biological Activity
It has been shown to inhibit the activity of detoxification enzymes and mitochondrial membrane potential, which may be responsible for its toxicity in insects. Cyflumetofen also causes a synergic effect with other chemicals, such as pesticides, by increasing their toxicity to insects.
Mechanism of action
cyflumetofen inhibited mitochondria complex II in mites. In addition, the de-esterified form (AB-1) of cyflumetofen inhibited mitochondria complex II at extremely low concentrations. AB-1 was also detected as the main metabolite in mites. The mode of action of cyflumetofen is to inhibit mitochondria complex II by affecting its action site after being metabolised to AB-1. However, inhibition by cyflumetofen and AB-1 in other organisms was very weak. Selectivity for other organisms has contributed to differences in action site activities.
Check Digit Verification of cas no
The CAS Registry Mumber 400882-07-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,0,0,8,8 and 2 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 400882-07:
(8*4)+(7*0)+(6*0)+(5*8)+(4*8)+(3*2)+(2*0)+(1*7)=117
117 % 10 = 7
So 400882-07-7 is a valid CAS Registry Number.
InChI:InChI=1/C24H24F3NO4/c1-22(2,3)16-9-11-17(12-10-16)23(15-28,21(30)32-14-13-31-4)20(29)18-7-5-6-8-19(18)24(25,26)27/h5-12H,13-14H2,1-4H3
400882-07-7Relevant articles and documents
Design, synthesis and acaricidal activities of Cyflumetofen analogues based on carbon-silicon isosteric replacement
Beadle, Ryan,Cheng, Jiagao,Earley, Fergus G.,Li, Zhong,Maienfisch, Peter,Zhou, Cong
, (2020/04/30)
The application of a carbon-silicon bioisosteric replacement strategy to find new acaricides with improved properties led to the discovery of Sila-Cyflumetofen 6B, a novel and highly potent acaricide. The essential t-butyl group in the beta-ketonitrile ac
