40101-45-9

Basic information

• Product Name: 2-(3,5-dimethylphenyl)-1H-isoindole-1,3(2H)-dione
• Synonyms: 2-(3,5-dimethylphenyl)-1H-isoindole-1,3(2H)-dione
• CAS NO: 40101-45-9
• Molecular Formula: C₁₆H₁₃NO₂
• Molecular Weight: 251.28
• Mol File: 40101-45-9.mol
• Article Data: 11

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(3,5-dimethylphenyl)-1H-isoindole-1,3(2H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3,5-dimethylphenyl)-1H-isoindole-1,3(2H)-dione(40101-45-9)
• EPA Substance Registry System: 2-(3,5-dimethylphenyl)-1H-isoindole-1,3(2H)-dione(40101-45-9)

Safety Data

• Hazardous Substances Data: 40101-45-9(Hazardous Substances Data)

Upstream product

• 136918-14-4 phthalimide 
• 22445-41-6 3,5-dimethylphenyl iodide 
• 201230-82-2 carbon monoxide 
• 610-97-9 o-iodo-methyl-benzoic acid 
• 108-69-0 3,5-dimethylaminoaniline 
• 108-38-3 m-xylene 
• 85-44-9 phthalic anhydride 
• 69076-57-9 C₁₆H₁₅NO₃ 
• 3481-09-2 N-chlorophthalimide 
• 119072-55-8 tert-butylisonitrile 
• 2042-37-7 o-cyanobromobenzene 

Downstream Products

• 403798-56-1 2-(3,5-dimethylphenyl)-3-hydroxyisoindolin-1-one 

Relevant articles and documents

Visible-Light-Induced Metal-/Photocatalyst-Free C-H Bond Imidation of Arenes

In this study, a visible-light-induced intermolecular C-H bond imidation of arenes was achieved at ambient condition. By using simple phthalimide with (diacetoxyiodo)benzene and molecular iodine, direct metal-/photocatalyst-free C-N bond formation was achieved. The imidation protocol was designed by using time-dependent density functional theory calculations and experimentally demonstrated for 28 substrates with as high as 96% yield. Mechanistic studies indicated that radical-mediated aromatic substitution occurred via photolysis of N-iodophthalimide under visible-light irradiation.

PdII/AgI-Catalyzed Room-Temperature Reaction of γ-Hydroxy Lactams: Mechanism, Scope, and Antistaphylococcal Activity

The present work reports a PdII/AgI-promoted amidoalkylation reaction involving various γ-hydroxy lactams and C/O/S nucleophiles at room temperature. The dual mode of activation of both the electrophile and nucleophile by in situ generated catalytically active cationic PdII species facilitates the reaction at room temperature. Among the synthesized isoindoline derivatives, three compounds are found to be active against vancomycin and methicillin-resistant S. aureus strain with appreciable MIC values.

Regioselective gold-catalyzed oxidative C-N bond formation

A novel protocol for the regioselective intermolecular amination of various arenes has been developed. By using an I(III) oxidant in the presence of a Au(I) catalyst, a direct and novel route for regioselectively accessing a variety of substituted aniline moieties has been achieved with yields as high as 90%. Mechanistic insight suggests that regioselectivity can be predicted based on electrophilic aromatic metalation patterns.