40106-98-7

Basic information

• Product Name: 4-CHLORO-5-NITROQUINOLINE
• Synonyms: 4-CHLORO-5-NITROQUINOLINE
• CAS NO: 40106-98-7
• Molecular Formula: C₉H₅ClN₂O₂
• Molecular Weight: 208.6
• Mol File: 40106-98-7.mol
• Article Data: 4

Chemical Properties

• Melting Point: 149-150 °C
• Boiling Point: 339.9±27.0 °C(Predicted)
• Appearance: /
• Density: 1.484±0.06 g/cm3(Predicted)
• PKA: 1.39±0.25(Predicted)
• CAS DataBase Reference: 4-CHLORO-5-NITROQUINOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-5-NITROQUINOLINE(40106-98-7)
• EPA Substance Registry System: 4-CHLORO-5-NITROQUINOLINE(40106-98-7)

Safety Data

• Hazardous Substances Data: 40106-98-7(Hazardous Substances Data)

Usage

General Description

4-Chloro-5-nitroquinoline is a chemical compound with the molecular formula C9H6ClN3O2. It is a yellow crystalline solid with a molecular weight of 221.61 g/mol. 4-CHLORO-5-NITROQUINOLINE is used primarily as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. Its chemical structure consists of a quinoline ring with a chlorine atom at the 4-position and a nitro group at the 5-position. It is also known to have antimicrobial and antiparasitic properties, making it a valuable building block in the development of new therapeutic agents. Additionally, 4-Chloro-5-nitroquinoline may also be used as a fluorescent probe in biochemical and cell biology research.

Upstream product

• 607-34-1 5-nitroquinoline 
• 529-37-3 4(1H)-quinolinone 
• 611-35-8 4-chloroquinoline 
• 7664-93-9 sulfuric acid 
• 7697-37-2 nitric acid 
• 40107-10-6 ethyl α-ethoxycarbonyl-β-(m-nitroanilino)acrylate 
• 7613-19-6 5-nitro-quinoline-1-oxide 

Downstream Products

• 658710-33-9 N-(5-nitroquinolin-4-yl)-N-[2-(N,N-dimethylamino)ethyl]-2-iodo-4,5-dimethoxybenzamide 
• 80552-29-0 5-nitro-4-(N,N-dimethylaminopropylamino)quinoline 
• 23536-75-6 4-Hydroxy-5-nitrochinolin 

Relevant articles and documents

Effects of the Distance between Radical Sites on the Reactivities of Aromatic Biradicals

Coupling of the radical sites in isomeric benzynes is known to hinder their radical reactivity. In order to determine how far apart the radical sites must be for them not to interact, the gas-phase reactivity of several isomeric protonated (iso)quinoline-and acridine-based biradicals was examined. All the (iso)quinolinium-based biradicals were found to react slower than the related monoradicals with similar vertical electron affinities (i.e., similar polar effects). In sharp contrast, the acridinium-based biradicals, most with the radical sites farther apart than in the (iso)quinolinium-based systems, showed greater reactivities than the relevant monoradicals with similar vertical electron affinities. The greater distances between the two radical sites in these biradicals lead to very little or no spin-spin coupling, and no suppression of radical reactivity was observed. Therefore, the radical sites can still interact if they are located on adjacent benzene rings and only after being separated further than that does no coupling occur. The most reactive radical site of each biradical was experimentally determined to be the one predicted to be more reactive based on the monoradical reactivity data. Therefore, the calculated vertical electron affinities of relevant monoradicals can be used to predict which radical site is most reactive in the biradicals.

NITRO AND AMINO SUBSTITUTED TOPOISOMERASE AGENTS

The invention provides compounds of formula 1 : wherein R1-R9, W, and X have any of the meanings defined in the specification and their pharmaceutically acceptable salts. The invention also provides pharmaceutical compositions comprising a compound of formula 1, processes for preparing compounds of formula 1, intermediates useful for preparing compounds of formula 1, and therapeutic methods for treating cancer using compounds of formula 1.