40114-95-2Relevant articles and documents
Visible-Light-Mediated C-H Alkylation of Pyridine Derivatives
Rammal, Fatima,Gao, Di,Boujnah, Sondes,Gaumont, Annie-Claude,Hussein, Aqeel A.,Lakhdar, Sami
, p. 7671 - 7675 (2020/10/09)
We report herein a visible-light-mediated C-H alkylation of pyridine derivatives that proceeds by simple combination of a large variety of N-alkoxypyridinium ions with alkanes in the presence of 2 mol % of fac-Ir(ppy)3 under blue illumination. The mild reaction conditions together with the high group functional tolerance make of this process a useful synthetic platform for the construction of structurally strained heterocycles. Detailed mechanistic investigations, including density functional theory calculations and quantum yield measurement, allowed us to understand factors controlling the reactivity and the selectivity of the reaction.
Transition-metal-free cross-dehydrogenative alkylation of pyridines under neutral conditions
Li, Xin,Wang, Hao-Yuan,Shi, Zhang-Jie
, p. 1704 - 1706 (2013/07/04)
A mild and efficient method has been developed for the direct dehydrogenative alkylation of unprotonated pyridine derivatives. The avoidance of using acids and transition-metals makes this protocol greener and more practical for the synthesis of substituted pyridines.
A novel radical reaction of alkyl xantates useful for the selective substitution of heteroaromatic bases
Coppa, Fausta,Fontaria, Francesca,Minisci, Francesco,Pianese, Giuseppe,Tortoreto, Paola,Zhao, Lihua
, p. 687 - 690 (2007/10/02)
Cyclohexyl radical is generated from cyclohexyldithiocarbonate and benzoyl peroxide. The radical source is used for the alkylation of heteroaromatic bases.
