40132-01-2

Basic information

• Product Name: 4-broMo-1-(4-fluorophenyl)butan-1-one
• Synonyms: 4-broMo-1-(4-fluorophenyl)butan-1-one;4-broMo-1-(4-fluorophenyl)-1-butanone;1-Butanone, 4-bromo-1-(4-fluorophenyl)-;4-Bromo-1-(4-fluorophenyl)
• CAS NO: 40132-01-2
• Molecular Formula: C₁₀H₁₀BrFO
• Molecular Weight: 245.0882032
• Mol File: 40132-01-2.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-broMo-1-(4-fluorophenyl)butan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-broMo-1-(4-fluorophenyl)butan-1-one(40132-01-2)
• EPA Substance Registry System: 4-broMo-1-(4-fluorophenyl)butan-1-one(40132-01-2)

Safety Data

• Hazardous Substances Data: 40132-01-2(Hazardous Substances Data)

Usage

General Description

4-bromo-1-(4-fluorophenyl)butan-1-one, also known as 4-bromo-4'-fluoro-1-phenylbutan-1-one, is a chemical compound made up of a bromine atom and a fluorine atom that are connected to two different phenyl groups. 4-broMo-1-(4-fluorophenyl)butan-1-one belongs to the class of organic compounds known as Benzene and substituted derivatives - organic compounds that contain one monocyclic ring of carbon atoms that is substituted with aromatic properties. The structural formula of this compound is found in the phenylbutanone family, specifically the single-bonded type of 4-bromobutan-1-one group attached with -4-fluorophenyl substructure. Various laboratories produce it for research and chemical studies. It must be handled with special care due to its reactive nature, as incorrect or unsafe handling could lead to hazardous results.

Upstream product

• 462-06-6 fluorobenzene 
• 927-58-2 4-bromobutyroyl chloride 
• 130387-74-5 4-fluorophenylmagnesium chloride 
• 89326-70-5 1-bromo-4-(4-fluorophenyl)-butane 
• 339365-53-6 1-(4-fluorophenyl)cyclobutan-1-ol 

Downstream Products

• 88327-90-6 2-[4-(4-Fluoro-phenyl)-4-oxo-butyl]-hexahydro-pyrido[1,2-a]pyrazin-1-one 
• 24678-13-5 lenperone 
• 1219-35-8 γ-piperidino-p-fluorobutyrophenone 
• 51787-84-9 4-(1,4-dioxa-8-azaspiro<4.5>dec-8-yl)-4'-fluorobutyrophenone 
• 19695-21-7 1-(4-fluorophenyl)-4-(4-hydroxypiperidin-1-yl)butan-1-one 
• 3575-80-2 melperone 
• 1467720-34-8 1-(4-fluorophenyl)-4-(vinylthio)butan-1-ol 
• 1467720-28-0 1-(4-fluorophenyl)-4-mercaptobutan-1-ol 
• 1467720-22-4 C₁₀H₁₂BrFO 
• 79108-56-8 1-(4-Fluoro-phenyl)-4-(7-methyl-3,4,6,7,12,12a-hexahydro-1H-pyrazino[1',2':1,6]pyrido[3,4-b]indol-2-yl)-butan-1-one 
• 143790-25-4 1-[4-(4-Fluoro-phenyl)-4-oxo-butyl]-piperidine-3-carboxylic acid 
• 58038-77-0 4-[8-fluoro-5-(4-fluoro-phenyl)-1,3,4,5-tetrahydro-pyrido[4,3-b]indol-2-yl]-1-(4-fluoro-phenyl)-butan-1-one 

Relevant articles and documents

Transition-Metal-Free Ring-Opening Reaction of 2-Halocyclobutanols through Ring Contraction

The present work describes the preparation of halohydrins from 2-halocyclobutanones by means of reactions with Grignard reagents at ?78 °C. We discovered that the prepared cyclobutanols underwent a thermal ring-opening reaction. Depending on the structure of the starting cyclobutanol, different products were formed. More specifically, 1-substituted 2-bromocyclobutan-1-ol was found to open to γ-substituted butyrophenones. A novel 1,3-dihydro-2H-inden-2-ylidene derivative was obtained for indene-derived cyclobutanols. Based on the outcomes of the performed experiments, a mechanism for the ring-opening of cyclobutanols can be proposed.

Intramolecular Cyclization of Brominated Oxime Ether Promoted with Ytterbium(0) to the Synthesis of Cyclic Imines

The first utility of ytterbium(0) as a mediating-metal in the intramolecular cyclization of brominated oxime ether was reported in this paper. In contrast to the prior methods, the N–O bond was used as a receptor of nucleophilic reagent, rather than as a source of N-centered radicals. Cyclic imines were obtained in this one-pot reaction with a broad scope of substrates and feasible reaction conditions.

Visible-light-enhanced ring opening of cycloalkanols enabled by br?nsted base-tethered acyloxy radical induced hydrogen atom transfer-electron transfer

A metal-free ring opening/halogenation of cycloalkanols, which combines both PPO/TBAX oxidant system and blue LEDs irradiation, is presented. This method produces diverse γ, α, and even more remotely halogenated ketones in moderate to excellent yields under mild conditions. Interestingly, experimental and computational studies demonstrate the novel ring size-dependent concerted/stepwise (four-/five- to eight-membered rings) hydrogen atom transfer-electron transfer induced by Br?nsted base-tethered acyloxy radical, which indicates distinct advantages brought by the cyclic structure of diacyl peroxides.