40248-84-8

Basic information

• Product Name: 3-Hydroxythiophenol
• Synonyms: 3-MERCAPTOPHENOL;3-HYDROXYTHIOPHENOL;3-HYDROXYBENZENETHIOL;M-HYDROXYBENZENETHIOL;m-Hydroxy Thiophenol;3-MERCAPTOPHENOL 98%;Phenol, 3-mercapto- (9CI);3-Hydroxy
• CAS NO: 40248-84-8
• Molecular Formula: C₆H₆OS
• Molecular Weight: 126.18
• Product Categories: THIOL;Phenol&Thiophenol&Mercaptan;Phenoles and thiophenoles;Miscellaneous
• Mol File: 40248-84-8.mol
• Article Data: 8

Chemical Properties

• Melting Point: 16-17 °C(lit.)
• Boiling Point: 242-243 °C(lit.)
• Flash Point: >230 °F
• Appearance: Clear colorless to pale yellow/Liquid
• Density: 1.237 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.00967mmHg at 25°C
• Refractive Index: n20/D >1.6290(lit.)
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 6.50±0.10(Predicted)
• Sensitive: Stench
• CAS DataBase Reference: 3-Hydroxythiophenol(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Hydroxythiophenol(40248-84-8)
• EPA Substance Registry System: 3-Hydroxythiophenol(40248-84-8)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36-36/37/38-20/21/22
• Safety Statements: 26-36-7/9
• RIDADR: UN 3334
• WGK Germany: 3
• HazardClass: IRRITANT, AIR SENSITIVE, STENCH
• Hazardous Substances Data: 40248-84-8(Hazardous Substances Data)

Usage

Chemical Properties

Colorless liquid

Uses

3-mercaptophenol may be used in the synthesis of the following:4-(3-hydroxyphenylthio)naphthalene-1,2-dione, which shows fluorosence emission[C6H4-1-(SPPh2)-3-(OPPh2)], a non-symmetric ligand which can combine with PdCl2 to form a pincer complex

General Description

3-mercaptophenol coated cantilevers can be used as formaldehyde sensors since it is highly selective towards formaldehyde and can show highest downward deflection on coming in contact with it.

InChI:InChI=1/C6H6OS/c7-5-2-1-3-6(8)4-5/h1-4,7-8H

Upstream product

• 36971-28-5 3-Bromo-(trimethylsilyloxy)benzene 
• 626-02-8 3-Iodophenol 
• 56157-93-8 3-hydroxybenzene-1-sulfonyl chloride 
• 15570-12-4 3-methoxybenzenethiol 
• 22948-02-3 3-aminothiophenol 
• 591-20-8 3-Bromophenol 
• 21101-56-4 3,3’-dihydroxydiphenyl disulfide 
• 7647-01-0 hydrogenchloride 
• 2388-74-1 1-methoxy-3-methylsulfanyl-benzene 

Downstream Products

• 412299-70-8 2-((3-hydroxyphenyl)thio)-1-phenylethan-1-one 
• 76039-59-3 3-hydroxy-2'-nitrodiphenyl sulphide 
• 127906-18-7 N,N-dimethyl-2-(3-hydroxyphenylthio)benzylamine 
• 127906-80-3 N,N-dimethyl-2-(3-hydroxyphenylthio)benzamide 
• 71681-94-2 C₆H₅OS^(1-)*Na⁽¹⁺⁾ 
• 1007165-67-4 (3-(benzyloxy)phenyl)(3-chloro-4-nitrophenyl)sulfane 
• 1007165-40-3 1-(4-(3-(benzyloxy)phenylthio)-2-chlorophenyl)ethanone 
• 1007165-48-1 4-methoxybenzyl 4-(3-(benzyloxy)phenylthio)-3-(trifluoromethyl)benzoate 
• 1337894-77-5 C₃₅H₃₆F₂O₇S 
• 1337894-79-7 C₁₄H₁₂O₂S 
• 1602920-41-1 C₁₈H₃₂OP₂S 
• 3463-03-4 3-methylsulfanylphenol 

Relevant articles and documents

Improved 3-hydroxythiophenol synthesis

Hydroxythiophenols have provided access to a number of unique heterocycles. Historically, access to 3-hydroxythiophenol has been challenging because of inefficiencies and prohibitive cost. A straightforward and efficient route to 3-hydroxythiphenol has been devised.

SINGLE-STEP SYNTHESIS METHOD OF ARYL THIOL AND APPLICATION THEREOF

The present invention relates to a single-step synthesis method of aryl thiol, and more specifically, to a method of synthesizing aryl thiol in a single-step by making aryl halide react with alkane dithiol in the presence of a transition metal catalyst. According to the present invention, a single-step synthesis method using the transition metal catalyst, the synthesis method which is capable of synthesizing aryl thiol from aryl halide at a high yield, can be provided. Various aryl halides may be applied to the synthesis method. Further, the synthesis method has advantages that an easily usable reagent may be used, operations are simple, and reactions can be performed under mild conditions. In addition, the synthesized aryl thiol may be used in the synthesis of advanced molecules such as diaryl sulfides and benzothiophenes.COPYRIGHT KIPO 2017

Practical and scaleable syntheses of 3-hydroxythiophenol

3-Hydroxythiophenol is a versatile intermediate for the synthesis of medicinal and heterocyclic compounds. Two novel and practical syntheses of 3-hydroxythiophenol are achieved using readily available and inexpensive starting materials. An overall cost comparison of these syntheses is also given.