402944-81-4

Basic information

• Product Name: 3-(1H-BENZOIMIDAZOL-2-YL)-BENZOIC ACID
• Synonyms: 3-(1H-BENZOIMIDAZOL-2-YL)-BENZOIC ACID;3-(1H-Benzimidazol-2-yl)benzoic acid;3-(1H-benzo[d]iMidazol-2-yl)benzoic acid;2-(3-Carboxyphenyl)-1H-benzimidazole
• CAS NO: 402944-81-4
• Molecular Formula: C14H10N2O2
• Molecular Weight: 238.24
• Product Categories: Benzimidazoles;Building Blocks;Chemical Synthesis;Heterocyclic Building Blocks;New Products for Chemical Synthesis
• Mol File: 402944-81-4.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 530.4 °C at 760 mmHg
• Flash Point: 274.6 °C
• Appearance: /
• Density: 1.377g/cm³
• Vapor Pressure: 4.44E-12mmHg at 25°C
• Refractive Index: 1.717
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 3-(1H-BENZOIMIDAZOL-2-YL)-BENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(1H-BENZOIMIDAZOL-2-YL)-BENZOIC ACID(402944-81-4)
• EPA Substance Registry System: 3-(1H-BENZOIMIDAZOL-2-YL)-BENZOIC ACID(402944-81-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26
• WGK Germany: 3
• Hazardous Substances Data: 402944-81-4(Hazardous Substances Data)

Usage

General Description

3-(1H-benzoimidazol-2-yl)-benzoic acid is a chemical compound with the molecular formula C15H10N2O2. It is a derivative of benzoic acid and features a benzoimidazole ring system, which gives it unique properties. 3-(1H-BENZOIMIDAZOL-2-YL)-BENZOIC ACID is often used in pharmaceutical research for its potential therapeutic properties, including anti-inflammatory and anti-cancer activities. It can also serve as a building block in the synthesis of other biologically active compounds. The presence of both a carboxylic acid and a heterocyclic ring makes 3-(1H-benzoimidazol-2-yl)-benzoic acid a versatile molecule with potential applications in various fields of chemistry and medicine.

InChI:InChI=1/C14H10N2O2/c17-14(18)10-5-3-4-9(8-10)13-15-11-6-1-2-7-12(11)16-13/h1-8H,(H,15,16)(H,17,18)

Upstream product

• 619-21-6 m-formylphenyl benzoic acid 
• 95-54-5 1,2-diamino-benzene 

Downstream Products

• 885463-19-4 2-(3-carboethoxyphenyl)benzimidazole 

Relevant articles and documents

Metal-organic framework mediated expeditious synthesis of benzimidazole and benzothiazole derivatives through an oxidative cyclization pathway

Herein, we report the facile synthesis of various benzimidazoles and benzothiazoles by using the NH2-MIL-125(Ti) MOF as an efficient oxidant-free heterogeneous catalyst with good yield. Adsorption of the substrate on the NH2-MIL-125(Ti) MOF surface through electron deficient Ti4+ sites initiates the reaction. The broad substrate scope and high reusability of this catalyst are attractive for synthesis of a wide range of medicinally active benzimidazole and benzothiazole derivatives.

Benzimidazol-2-yl or benzimidazol-2-ylthiomethyl benzoylguanidines as novel Na+/H+ exchanger inhibitors, synthesis and protection against ischemic-reperfusion injury

A novel series of benzimidazol-2-yl or benzimidazol-2-ylthiomethyl benzoylguanidines were designed and synthesized as Na+/H+exchanger inhibitors. Most of them were found to inhibit NHE1-mediated platelet swelling in a concentration-dependent manner, and to have significant cardioprotective effect against myocardial ischemic-reperfusion injury, among which compounds 10a and 34 were more potent than cariporide in both in vivo and in vitro tests.