402958-25-2

Basic information

• Product Name: (1S,3AR,6AS)-OCTAHYDRO-CYCLOPENTA[C]PYRROLE-1-CARBOXYLIC ACID ETHYL ESTER
• Synonyms: (1S,3A,6AS)-ETHYL OCTAHYDROCYCLOPENTA[C]PYRROLE-1-CARBOXYLATE HYDROCHLORIDE;(1S,3aR,6aS)-Octahydro-cyclopenta[clpyrrole-l-carboxylic acid ethyl ester;(1S,3AR,6AS)-OCTAHYDRO-CYCLOPENTA[C]PYRROLE-1-CARBOXYLIC ACID ETHYL ESTER;Telaprevir/VX950 Intermediate 1
• CAS NO: 402958-25-2
• Molecular Formula: C₁₀H₁₇NO₂
• Molecular Weight: 183.249
• Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals;Chiral Reagents;Heterocycles
• Mol File: 402958-25-2.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 255℃
• Flash Point: 108℃
• Appearance: White to off-white powder
• Density: 1.058
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: (1S,3AR,6AS)-OCTAHYDRO-CYCLOPENTA[C]PYRROLE-1-CARBOXYLIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: (1S,3AR,6AS)-OCTAHYDRO-CYCLOPENTA[C]PYRROLE-1-CARBOXYLIC ACID ETHYL ESTER(402958-25-2)
• EPA Substance Registry System: (1S,3AR,6AS)-OCTAHYDRO-CYCLOPENTA[C]PYRROLE-1-CARBOXYLIC ACID ETHYL ESTER(402958-25-2)

Safety Data

• Hazardous Substances Data: 402958-25-2(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 402958-25-2 differently. You can refer to the following data:
1. A bicyclic pyrrole derivative, (1S,3aR,6aS)-ethyl octahydrocyclopenta[c]pyrrole-1-carboxylate can be used in the preparation of hepatitis C virus (HCV) protease inhibitors.
2. A bicyclic pyrrole derivative used in the preparation of hepatitis C virus (HCV) protease inhibitors.

InChI:InChI=1S/C10H17NO2/c1-2-13-10(12)9-8-5-3-4-7(8)6-11-9/h7-9,11H,2-6H2,1H3/t7-,8-,9-/m0/s1

Upstream product

• 1227703-21-0 3-azabicyclo-[3,3,0]oct-2-ene 
• 1468-87-7 octahydrocyclopenta[c]pyrrole 
• 64-17-5 ethanol 
• 1227704-10-0 (1S,3aR,6aS)-2-(tert-butoxycarbonyl)octahydrocyclopenta[c]pyrrole-1-carboxylic acid (S)-1,2,3,4-tetrahydro-1-naphthylammonium salt 
• 791572-14-0 (3aR,6aS)-octahydrocyclopenta[c]pyrrole-1-carboxylic acid 
• 1227703-50-5 C₈H₁₂N₂ 
• 402958-22-9 (1S,3aR,6aS)-4-Hydroxy-hexahydro-cyclopenta[c]pyrrole-1,2-dicarboxylic acid 2-benzyl ester 1-ethyl ester 
• 667468-11-3 (1S,3aR,4R,6aS)-4-Hydroxy-hexahydro-cyclopenta[c]pyrrole-1,2-dicarboxylic acid 2-benzyl ester 1-ethyl ester 
• 402958-21-8 (1S,3aR,6aS)-4-Oxo-hexahydro-cyclopenta[c]pyrrole-1,2-dicarboxylic acid 2-benzyl ester 1-ethyl ester 
• 402958-24-1 (1S,3aR,6aS)-Hexahydro-cyclopenta[c]pyrrole-1,2-dicarboxylic acid 2-benzyl ester 1-ethyl ester 
• 402958-23-0 (1S,3aR,6aS)-4-Methylsulfanylthiocarboxyoxy-hexahydro-cyclopenta[c]pyrrole-1,2-dicarboxylic acid 2-benzyl ester 1-ethyl ester 

Downstream Products

• 1147103-66-9 (1S,3aR,6aS)-ethyl 2-((2S)-2-((2S,3R)-3-cyclohexyl-1,1,1-trifluoro-3-(pyrazine-2-carboxamido)propan-2-ylamino)-3,3-dimethylbutanoyl)octahydrocyclopenta[c]pyrrole-1-carboxylate 
• 402958-97-8 (1S,3aR,6aS)-ethyl 2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)octahydrocyclopenta[c]pyrrole-1-carboxylate 
• 402957-28-2 (1S,3aR,6aS)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide 
• 402959-36-8 (1S,3aR,6aS)-2-[(2S)-2-[[(2S)-2-cyclohexyl-2-[(2-pyrazinylcarbonyl)amino] acetyl]amino]-3,3-dimethylbutanoyl]-N-[(1S)-1-[(cyclopropylamino)(hydroxy)acetyl]butyl]-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrole-3-carboxamide 
• 402958-98-9 (1S,3aR,6aS)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)octahydrocyclopenta[c]pyrrole-1-carboxylic acid 
• 402958-30-9 (S)-2-(3-{[(1S,3aR,6aS)-2-((S)-3-Methyl-2-{(S)-3-methyl-2-[(pyrazine-2-carbonyl)-amino]-butyrylamino}-butyryl)-octahydro-cyclopenta[c]pyrrole-1-carbonyl]-amino}-2-oxo-hexanoylamino)-3-phenyl-propionic acid tert-butyl ester 
• 402958-28-5 (S)-2-(2-Hydroxy-3-{[(1S,3aR,6aS)-2-((S)-3-methyl-2-{(S)-3-methyl-2-[(pyrazine-2-carbonyl)-amino]-butyrylamino}-butyryl)-octahydro-cyclopenta[c]pyrrole-1-carbonyl]-amino}-hexanoylamino)-3-phenyl-propionic acid tert-butyl ester 
• 669082-22-8 [(S)-1-((1S,3aR,6aS)-1-{1-[Hydroxy-((S)-1-phenyl-ethylcarbamoyl)-methyl]-butylcarbamoyl}-hexahydro-cyclopenta[c]pyrrole-2-carbonyl)-2,2-dimethyl-propyl]-carbamic acid isopropyl ester 
• 628729-11-3 [(S)-1-((1S,3aR,6aS)-1-{1-[Hydroxy-((S)-1-phenyl-ethylcarbamoyl)-methyl]-butylcarbamoyl}-hexahydro-cyclopenta[c]pyrrole-2-carbonyl)-2-methyl-propyl]-carbamic acid isopropyl ester 

Relevant articles and documents

Telaprevir intermediate preparation method

The invention relates to a preparation method of cyclopentane [c] pyrrole compound (formula I), and the method comprises following steps: taking 3-diaza-bicyclo [3.3.0] octane as the raw material, and then subjecting the raw material to cyanation, hydrolysis and esterification reactions so as to obtain the target product. The preparation method has the advantages of simple and easy operation, high yield, high product purity, and suitability for industrial production.

Discovery of a novel bicycloproline P2 bearing peptidyl α-ketoamide LY514962 as HCV protease inhibitor

We describe herein the design, syntheses and evaluation of a number of bicycloproline P2 bearing HCV protease inhibitors endowed with impressive enzyme potency, enzyme selectivity, cellular activity and favorable ADME profiles.