403-21-4

Basic information

• Product Name: 3-Fluoro-4-nitrobenzoic acid
• Synonyms: 3-FLUORO-4-NITROBENZENECARBOXYLIC ACID;3-FLUORO-4-NITROBENZOIC ACID;BUTTPARK 32\01-75;3-Fluoro-4-nitrobenzoicacid95%;3-FLUORO-4-NITROBENZOIC CAID ;3-Fluoro-4-nitrobenzoic;3-Fluoro-4-nitrobenzoic acid 99%;3-Fluoro-4-nitrobenzoicacid99%
• CAS NO: 403-21-4
• Molecular Formula: C₇H₄FNO₄
• Molecular Weight: 185.11
• Product Categories: blocks;Carboxes;FluoroCompounds;NitroCompounds;Acids and Derivatives;Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Miscellaneous;Carboxylic Acids;Phenyls & Phenyl-Het
• Mol File: 403-21-4.mol
• Article Data: 23

Chemical Properties

• Melting Point: 174-175°C
• Boiling Point: 372.8 °C at 760 mmHg
• Flash Point: 179.3 °C
• Appearance: /
• Density: 1.568 g/cm³
• Vapor Pressure: 3.23E-06mmHg at 25°C
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: soluble in Methanol
• PKA: 3.08±0.10(Predicted)
• CAS DataBase Reference: 3-Fluoro-4-nitrobenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Fluoro-4-nitrobenzoic acid(403-21-4)
• EPA Substance Registry System: 3-Fluoro-4-nitrobenzoic acid(403-21-4)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-37/38-36-22
• Safety Statements: 26-36/37/39-37
• HazardClass: IRRITANT
• Hazardous Substances Data: 403-21-4(Hazardous Substances Data)

Usage

Uses

3-Fluoro-4-nitrobenzoic Acid is used in the synthesis of ABT-072, a non-nucleoside HCV NS5B polymerase inhibitor.

InChI:InChI=1/C7H4FNO4/c8-5-3-4(7(10)11)1-2-6(5)9(12)13/h1-3H,(H,10,11)/p-1

Upstream product

• 446-34-4 2-fluoro-4-methyl-1-nitrobenzene 
• 86790-39-8 (±)-methyl 2-(4-nitro-3-fluorophenyl)propanoate 
• 578-46-1 5-methyl-2-nitroaniline 
• 1493-27-2 ortho-nitrofluorobenzene 
• 503315-74-0 (3-fluoro-4-nitrophenyl)methanol 

Downstream Products

• 85803-26-5 di-tert-butyl N-(3-fluoro-4-nitrobenzoyl)-l-glutamate 
• 157665-53-7 tert-butyl 3-fluoro-4-aminobenzoate 
• 157665-52-6 3-fluoro-4-nitrobenzoic acid t-butyl ester 
• 157665-54-8 tert-butyl 3-fluoro-4-benzoate 
• 157665-57-1 tert-butyl 3-fluoro-4-benzoate 
• 157665-56-0 tert-butyl 3-fluoro-4-<(2-chloroethyl)-<2-(mesyloxy)ethyl>amino>benzoate 
• 157665-55-9 tert-butyl 3-fluoro-4-amino>benzoate 
• 658700-15-3 tert-butyl N-(3-fluoro-4-nitrophenyl)carbamate 
• 2369-13-3 3-fluoro-4-nitroaniline 
• 185629-31-6 methyl 3-fluoro-4-nitrobenzoate 
• 367501-32-4 3-ethoxy-4-nitro-benzoic acid 
• 193014-31-2 ethyl 3-[sec-(2,4-dichlorophenetyl)amino]-4-nitrobenzoate 
• 1261276-81-6 C₃₂H₂₆F₃N₅O₃S 
• 1261277-21-7 C₂₃H₂₀FN₃O₂S 

Relevant articles and documents

Continuous synthesis method for substituted benzoic acid organic matter

The invention provides a continuous synthesis method for a substituted benzoic acid organic matter. The continuous synthesis method comprises the following steps: in the presence of a catalyst and anorganic solvent, continuously putting an organic matter of a formula (I) shown in the specification, and oxygen into a continuous reaction device, carrying out a continuous oxidation reaction so as toobtain the substituted benzoic acid organic matter, and continuously discharging the substituted benzoic acid organic matter, wherein the substituted benzoic acid organic matter is of a structure ofa formula (II) shown in the specification. Oxygen is a green reagent and is cheap and easy to obtain, a great amount of wastes are not generated after reactions are completed, and the system is easy to treat. Due to continuous reaction operation, the risk that the solvent has flash evaporation explosion because of high-concentration oxygen in in-batch reactions can be reduced. Under same oxidationconditions, due to a continuous preparation process, escape of oxygen can be reduced, the utilization rate of oxygen can be greatly increased, operation can be also simplified, the security of reactions can be improved, and the yield of the substituted benzoic acid organic matter can be increased.

PYRROLE ANTIFUNGAL AGENTS

The invention provides compounds of formula (I), and pharmaceutically and agriculturally acceptable salts thereof; wherein: R1, R2, R3, R4, R5, R6, A1, L1 and n are as defined herein. These compounds and their pharmaceutically acceptable salts are useful in prevention or treatment of a fungal disease. Compounds of formula (I), and agriculturally acceptable salts thereof, may also be used as agricultural fungicides.

Pyrimido-Benzimidazole Derivatives and the Use Thereof in the Form of Agonists and Antagonists of Melanocortin Receptors

The invention relates to novel pyrimido-benzimidazole derivatives. Said products exhibit a good affinity for certain melanocortin receptor sub-types, in particular MC4 receptors. Said products represent a particular interest for treating pathological disorders and diseases associated with one or several melanocortin receptors. Pharmaceutical compositions containing said products and the use thereof for a drug preparation are also disclosed.