404337-71-9

Basic information

• Product Name: (R)-ChroMan-2-ylMethanaine
• Synonyms: (R)-ChroMan-2-ylMethanaine;(2R)-3,4-Dihydro-2H-1-benzopyran-2-methanamine;(R)-2-Aminomethylchroman;[(2R)-Chroman-2-yl]methanamine;(R)-CHROMAN-2-YLMETHANAMINE
• CAS NO: 404337-71-9
• Molecular Formula: C₁₀H₁₃NO
• Molecular Weight: 148.20168
• Product Categories: Heterocycle-other series
• Mol File: 404337-71-9.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 278.951 °C at 760 mmHg
• Flash Point: 129.241 °C
• Appearance: /
• Density: 1.073 g/cm³
• Vapor Pressure: 0.004mmHg at 25°C
• Refractive Index: 1.548
• PKA: 9.14±0.29(Predicted)
• CAS DataBase Reference: (R)-ChroMan-2-ylMethanaine(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-ChroMan-2-ylMethanaine(404337-71-9)
• EPA Substance Registry System: (R)-ChroMan-2-ylMethanaine(404337-71-9)

Safety Data

• Hazardous Substances Data: 404337-71-9(Hazardous Substances Data)

Usage

General Description

(R)-Chroman-2-ylmethanamine is a chemical compound with the molecular formula C10H13N. It is a derivative of chroman, a bicyclic organic compound, and is commonly used as a precursor in the synthesis of various pharmaceuticals and organic compounds. Its structure consists of a chroman ring system with an attached methanamine group. (R)-Chroman-2-ylmethanaine possesses certain pharmacological properties and may have potential applications in the development of new drugs or medications. Additionally, (R)-Chroman-2-ylmethanamine is also a useful reagent in organic synthesis and chemical research. Its specific properties and potential uses make it a subject of interest for scientists and researchers in various fields.

InChI:InChI=1/C10H13NO/c11-7-9-6-5-8-3-1-2-4-10(8)12-9/h1-4,9H,5-7,11H2/t9-/m1/s1

Upstream product

• 83780-47-6 (-)-(R)-3,4-dihydro-2H-1-benzopyran-2-carboxylic acid 
• 227466-91-3 (R)-chroman-2-carboxylic acid chloride 
• 480438-46-8 Grignard reagent from 2-methoxybenzyl chloride 
• 51939-71-0 chroman-2-carboxylic acid 
• 955124-58-0 (R)-(+)-1-phenylpropylammonium (R)-(-)-chromane-2-carboxylate 
• 955124-65-9 (S)-1-(benzyloxy)-4-(2-methoxyphenyl)butan-2-ol 
• 955124-69-3 (S)-1-bromo-4-(2-hydroxy-phenyl)butan-2-yl acetate 
• 955124-67-1 (S)-1-bromo-4-(2-methoxy-phenyl)butan-2-yl acetate 
• 955124-71-7 (S)-2-(4-bromo-3-hydroxybutyl)phenol 
• 955124-73-9 (R)-2-(bromomethyl)chroman 
• 4940-39-0 acide chromone carboxylique-2 
• 66598-81-0 chroman-2-carboxylic acid methyl ester 
• 137590-28-4 ethyl 2,3-dihydrobenzopyran-(2R)-carboxylate 
• 24698-77-9 ethyl Chroman-2-carboxylate 

Downstream Products

• 149177-75-3 (2R)-3,4-dihydro-2H-chromen-2-ylmethylamine hydrochloride 
• 955124-60-4 (R)-tert-butyl (8-(2,6-dichlorophenyl)-2-chromanyl)methylcarbamate 

Relevant articles and documents

New serotonin 5-HT1A receptor agonists with neuroprotective effect against ischemic cell damage

We report the synthesis of new compounds 4-35 based on structural modifications of different moieties of previously described lead UCM-2550. The new nonpiperazine derivatives, representing second-generation agonists, were assessed for binding affinity, selectivity, and functional activity at the 5-HT1A receptor (5-HT1AR). Computational β2-based homology models of the ligand-receptor complexes were used to explain the observed structure-affinity relationships. Selected candidates were also evaluated for their potential in vitro and in vivo neuroprotective properties. Interestingly, compound 26 (2-{6-[(3,4-dihydro-2H- chromen-2-ylmethyl)amino]hexyl}tetrahydro-1H-pyrrolo[1,2-c]imidazole-1,3(2H) -dione) has been characterized as a high-affinity and potent 5-HT1AR agonist (Ki = 5.9 nM, EC50 = 21.8 nM) and exhibits neuroprotective effect in neurotoxicity assays in primary cell cultures from rat hippocampus and in the MCAO model of focal cerebral ischemia in rats.

METHOD FOR PRODUCING CHROMANE DERIVATIVES THAT ARE DEVOID OF ENANTIOMERS AND ARE SUBSTITUTED IN POSITION 2

The invention relates to a method for producing chromane derivatives that are devoid of enantiomers and are substituted in position 2, from corresponding chromane-2-carboxylic acid esters.

CHROMANONE DERIVATIVES

Chromanone derivatives of the formula I in which R1 to R4 are each, independently of one another, H, A, CN, Hal, OR5, COOR5, CF3, OCF3, NO2, Ar, OAr, N(R5)2 /sub