404964-34-7

Basic information

• Product Name: 5-fluoro-2-chlorosulfonyl-3-Methylbenzo[b]thiophene
• Synonyms: 5-fluoro-2-chlorosulfonyl-3-Methylbenzo[b]thiophene;5-Fluoro-3-methyl-1-benzothiophene-2-sulphonyl chloride, 2-(Chlorosulphonyl)-5-fluoro-3-methylbenzo[b]thiophene;5-Fluoro-3-Methyl-1-benzothiophene-2-sulfonyl chloride
• CAS NO: 404964-34-7
• Molecular Formula: C₉H₆ClFO₂S₂
• Molecular Weight: 264.7241432
• Mol File: 404964-34-7.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-fluoro-2-chlorosulfonyl-3-Methylbenzo[b]thiophene(CAS DataBase Reference)
• NIST Chemistry Reference: 5-fluoro-2-chlorosulfonyl-3-Methylbenzo[b]thiophene(404964-34-7)
• EPA Substance Registry System: 5-fluoro-2-chlorosulfonyl-3-Methylbenzo[b]thiophene(404964-34-7)

Safety Data

• Hazardous Substances Data: 404964-34-7(Hazardous Substances Data)

Upstream product

• 1353433-16-5 5-fluoro-3-methyl-benzo[b]thiophene-2-sulfonic acid 
• 2968-13-0 1-(4-fluoro-phenylsulfanyl)propan-2-one 
• 371-42-6 4-Fluorothiophenol 
• 17514-63-5 5-fluoro-3-methyl-benzo[b]thiophene 

Downstream Products

• 1268481-27-1 N-(4,5-dichloro-2-{[(3,4-dichlorophenyl)sulfonyl]amino}phenyl)-5-fluoro-3-methyl-1-benzothiophene-2-sulfonamide 
• 1268481-05-5 5-fluoro-N-(2-{[(3,4-dichlorophenyl)sulfonyl]amino}phenyl)-3-methyl-1-benzothiophene-2-sulfonamide 
• 404963-90-2 TY-51076 
• 1037299-81-2 4-[4-(5-fluoro-3-methyl-benzo[b]thiophene-2-sulfonylamino)-3-methanesulfonyl-phenyl]-piperidine-1-carboxylic acid tert-butyl ester 
• 1037299-54-9 5-Fluoro-3-methyl-benzo[b]thiophene-2-sulfonic acid (4-pyridin-4-yl-phenyl)-amide 

Relevant articles and documents

NEW COMPOUNDS

A compound of formula (I), wherein A is S, O or a double bond, and L is a substituted thiazolyl, phenyl or pyridyl. The compound is useful for the treatment of inflammation and cancer.

Structure-activity relationship of benzo[b]thiophene-2-sulfonamide derivatives as novel human chymase inhibitors

We have identified a new class of chymase inhibitor through a substituent analysis of MWP00965, which we previously discovered by in silico screening. TY-51076 (7) showed high potency (IC50=56 nM) and excellent selectivity for chymase compared to chymotrypsin and cathepsin G (>400-fold). The synthesis and structure-activity relationship of this class are described.