405165-00-6 Usage
General Description
D-Proline, 3-hydroxy-, methyl ester, (3S)- (9CI) is a chemical compound that is a derivative of D-proline, an amino acid. It is a methyl ester of 3-hydroxy-D-proline, with the (3S)- stereochemistry. D-Proline, 3-hydroxy-, methyl ester, (3S)- (9CI) has potential biological and pharmaceutical applications, as proline derivatives have been found to have various medicinal properties, such as anti-inflammatory, analgesic, and anticancer effects. The methyl ester form of 3-hydroxy-D-proline may be used in the synthesis of pharmaceuticals or as a research tool in the study of proline derivatives and their biological activities.
Check Digit Verification of cas no
The CAS Registry Mumber 405165-00-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,0,5,1,6 and 5 respectively; the second part has 2 digits, 0 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 405165-00:
(8*4)+(7*0)+(6*5)+(5*1)+(4*6)+(3*5)+(2*0)+(1*0)=106
106 % 10 = 6
So 405165-00-6 is a valid CAS Registry Number.
InChI:InChI=1/C6H11NO3/c1-10-6(9)5-4(8)2-3-7-5/h4-5,7-8H,2-3H2,1H3/t4-,5+/m0/s1
405165-00-6Relevant articles and documents
2-Substituted Penems with Amino Acid-Related Side Chains: Synthesis and Antibacterial Activity of a New Series of β-Lactam Antibiotics
Altamura, Maria,Perrotta, Enzo,Sbraci, Piero,Pestellini, Vittorio,Arcamone, Federico,et al.
, p. 4244 - 4256 (2007/10/03)
A new series of 6-(hydroxyethyl)penems 2-substituted with amino acid-related side chains was synthesized.The nature of the amino acyl derivative proved to be crucial both from a synthetic point of view, as β-lactam ring opening can compete with C-2 nucleophilic substitution, and for antibacterial activity.Primary amino acid amides emerged as the most suitable side chains for enhancing permeability through a Gram-negative outer membrane.In vitro activity of the new 2-penems 3a-u was influenced by the nature and position of the amide moiety, the ring size for cyclic amides, and the configuration of the amino acid.Compounds bearing amides derived from small N-methyl amino acids (such as 3a) or from cyclic amino acids (such as prolinamide 3p and 4-hydroxyprolinamide 3r) showed broad spectrum in vitro activity against both Gram-positive and Gram-negative microorganisms.
