40517-43-9

Basic information

• Product Name: P-(METHYLSULFONYL)BENZYL CHLORIDE
• Synonyms: 1-CHLOROMETHYL-4-METHANESULFONYL-BENZENE;4-(METHYLSULFONYL)BENZYL CHLORIDE;P-(METHYLSULFONYL)BENZYL CHLORIDE;4-Methanesulfonylbenzyl chloride;Benzene, 1-(chloroMethyl)-4-(Methylsulfonyl)-
• CAS NO: 40517-43-9
• Molecular Formula: C₈H₉ClO₂S
• Molecular Weight: 204.67
• Mol File: 40517-43-9.mol
• Article Data: 7

Chemical Properties

• Melting Point: 78-80°C
• Boiling Point: 365 °C at 760 mmHg
• Flash Point: 174.5 °C
• Appearance: /
• Density: 1.287
• Vapor Pressure: 3.41E-05mmHg at 25°C
• Refractive Index: 1.537
• CAS DataBase Reference: P-(METHYLSULFONYL)BENZYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: P-(METHYLSULFONYL)BENZYL CHLORIDE(40517-43-9)
• EPA Substance Registry System: P-(METHYLSULFONYL)BENZYL CHLORIDE(40517-43-9)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT, LACHRYMATOR
• Hazardous Substances Data: 40517-43-9(Hazardous Substances Data)

Usage

General Description

P-(methylsulfonyl)benzyl chloride is a chemical compound with the molecular formula C8H9ClO2S. It is a chlorinated derivative of the compound benzyl chloride, with a methylsulfonyl group attached to the para position of the benzene ring. P-(METHYLSULFONYL)BENZYL CHLORIDE is commonly used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It is also used as a reagent in organic chemistry reactions, specifically in the formation of carbon-carbon and carbon-nitrogen bonds. P-(methylsulfonyl)benzyl chloride is a colorless to pale yellow liquid with a pungent odor, and it should be handled and stored with caution due to its potential toxicity and reactivity.

InChI:InChI=1/C8H9ClO2S/c1-12(10,11)8-4-2-7(6-9)3-5-8/h2-5H,6H2,1H3

Upstream product

• 4052-30-6 4-methylsulfonylbenzoic acid 
• 22821-77-8 p-methylsulfonylbenzyl alcohol 
• 124-63-0 methanesulfonyl chloride 
• 58472-47-2 4-methylsulfinylbenzyl chloride 
• 13205-48-6 4-(methylthio)benzoic acid 
• 3446-90-0 4-(methylthio)benzyl alcohol 
• 22821-70-1 methyl 4-(methanesulfonyl)benzoate 
• 6274-54-0 methylsulfonyl-4 benzoate d'ethyle 
• 3185-99-7 Methyl p-tolyl sulfone 
• 100960-84-7 (4-iodomethyl-phenyl)-methyl sulfone 

Downstream Products

• 100960-84-7 (4-iodomethyl-phenyl)-methyl sulfone 
• 121083-05-4 (-)6,8-difluoro-9-p-methylsulfonyl benzyl-1,2,3,4-tetrahydrocarbazol-1-yl-acetic acid 
• 301220-85-9 4-((1-(4-methylsulfonylbenzyl)-3-ethyl)pyrazol-4-yl)-N-t-butoxylcarbonylpiperidine 
• 932708-49-1 2-(4-methanesulfonylbenzyl)-3-oxopentanoic acid methyl ester 
• 925220-77-5 C₁₈H₁₈N₂O₅S 
• 718610-85-6 [(N-boc-piperidin-4-yl)methyl]-(4-methanesulphonyl-phenylmethyl)sulphide 
• 910800-01-0 tert-butyl 8-[(4-methylpiperidin-1-yl)carbonyl]-5-[4-(methylsulfonyl)benzyl]-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxylate 
• 1361392-15-5 1-(cyclohexylmethyl)-4-(4-(methylsulfonyl)benzyl)piperazine 
• 1361392-16-6 (4-(5-ethylpyrimidin-2-yloxy)cyclohexyl)(4-(4-(methylsulfonyl)benzyl)piperazin-1-yl)methanone 
• 1082399-22-1 1-(4-(methylsulfonyl)benzyl)piperazine 
• 1419174-96-1 1-(2-methylenehexyl)-4-(methylsulfonyl)benzene 
• 1419175-03-3 5-(2-(4-(methylsulfonyl)benzyl)allyl)benzo[d][1,3]dioxole 
• 1227370-85-5 tert-butyl [6-fluoro-4-(4-methanesulfonylbenzyl)-3-methylnaphthalen-2-yl]acetate 
• 94429-35-3 4,4'-Di-(methylsulfon)-bibenzyl 

Relevant articles and documents

SPIRO COMPOUNDS AS GLYCOSIDASE INHIBITORS

Compounds of formula (I) wherein A, R, L, Z, Q1, Q2 and n have the meaning according to the claims can be employed, inter alia, for the treatment of tauopathies and Alzheimer's disease.

Derivatives of 1H-imidazole-4,5-dicarboxamide and Use Thereof in Preparation of Anticoccidial Drugs

Disclosed are derivatives of 1H-imidazole-4,5-dicarboxamide and use thereof in preparation of anticoccidial drugs. The derivatives have structural formulae as shown in formulae (I) to (VI). The derivatives of 1H-imidazole-4,5-dicarboxamide as disclosed in the present invention have significant anticoccidial effect, especially against coccidia that show a resistance to other anticoccidial drugs, and thus they can be used in preparation of anticoccidial drug.

Formamides as Lewis Base Catalysts in SNReactions—Efficient Transformation of Alcohols into Chlorides, Amines, and Ethers

A simple formamide catalyst facilitates the efficient transformation of alcohols into alkyl chlorides with benzoyl chloride as the sole reagent. These nucleophilic substitutions proceed through iminium-activated alcohols as intermediates. The novel method, which can be even performed under solvent-free conditions, is distinguished by an excellent functional group tolerance, scalability (>100 g) and waste-balance (E-factor down to 2). Chiral substrates are converted with excellent levels of stereochemical inversion (99 %→≥95 % ee). In a practical one-pot procedure, the primary formed chlorides can be further transformed into amines, azides, ethers, sulfides, and nitriles. The value of the method was demonstrated in straightforward syntheses of the drugs rac-Clopidogrel and S-Fendiline.