405274-94-4

Basic information

• Product Name: 5-BROMO-1-(2-FLUOROBENZYL)-1H-INDOLE-3-CARBALDEHYDE
• Synonyms: 5-BROMO-1-(2-FLUOROBENZYL)-1H-INDOLE-3-CARBALDEHYDE;1-(2-FLUOROBENZYL)-5-BROMO-1H-INDOLE-3-CARBALDEHYDE;5-bromo-1-(2-fluorobenzyl)-3-formyl-1H-indole
• CAS NO: 405274-94-4
• Molecular Formula: C₁₆H₁₁BrFNO
• Molecular Weight: 332.17
• Mol File: 405274-94-4.mol
• Article Data: 3

Chemical Properties

• Melting Point: 131-132 °C
• Boiling Point: 485.2±40.0 °C(Predicted)
• Appearance: /
• Density: 1.45±0.1 g/cm3(Predicted)
• CAS DataBase Reference: 5-BROMO-1-(2-FLUOROBENZYL)-1H-INDOLE-3-CARBALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BROMO-1-(2-FLUOROBENZYL)-1H-INDOLE-3-CARBALDEHYDE(405274-94-4)
• EPA Substance Registry System: 5-BROMO-1-(2-FLUOROBENZYL)-1H-INDOLE-3-CARBALDEHYDE(405274-94-4)

Safety Data

• Hazardous Substances Data: 405274-94-4(Hazardous Substances Data)

Upstream product

• 877-03-2 5-bromo-1H-indole-3-carboxaldehyde 
• 345-35-7 2-fluorobenzyl chloride 

Downstream Products

• 1283706-97-7 C₁₉H₁₃BrFN₃OS 
• 1574402-21-3 3-[5-bromo-1-(2-fluorobenzyl)-1H-indol-3-ylmethylene]-1-(2,6-dichlorophenyl)-1,3-dihydroindol-2-one 
• 558469-90-2 5-bromo-1-(2-fluorobenzyl)-3-hydroxymethyl-1H-indole 
• 1574402-17-7 4-[5-bromo-1-(2-fluorobenzyl)-1H-indol-3-ylmethylene]-2-(3-chlorophenyl)-5-methyl-2,4-dihydropyrazol-3-one 

Relevant articles and documents

Synthesis and in vitro screening of novel N-benzyl aplysinopsin analogs as potential anticancer agents

A series of novel substituted (Z)-5-((1-benzyl-1H-indol-3-yl)methylene) imidazolidin-2,4-diones (3a-f) and (Z)-5-((1-benzyl-1H-indol-3-yl)methylene)-2- iminothiazolidin-4-ones (3g-o) have been synthesized utilizing microwave irradiation. These analogs wer

Synthesis and antifungal activity of new 1-halogenobenzyl-3-imidazolylmethylindole derivatives

A series of 1-benzyl-3-(imidazol-1-ylmethyl)indole derivatives 35-46 were prepared under mild reaction conditions and tested for their antifungal activity. Pharmacomodulation at N1, C2 and C5 of the indole ring and at the level of the alkyl chain (R1) was carried out starting from the corresponding 3-acylindoles 6, 7 or 3-formylindoles 11-22. Target imidazolyl compounds 35-46 were obtained in satisfactory yields by CO2 elimination from the intermediate carbamates. All of the compounds were evaluated in vitro against two human fungal pathogens, Candida albicans (CA980001) and Aspergillus fumigatus (AF980003); amphotericin B, fluconazole and itraconazole were used as references. Seven out of 27 compounds (35b, 35e, 35g, 35h, 36a, 38a and especially 40a) exerted significant antifungal activity against C. albicans, with MIC in the range of 1-6 μg mL-1. As regards inhibitory activity against A. fumigatus, the MIC figures of most of our compounds were in excess of 20 μg mL-1 in contrast to the reference drugs, amphotericin B and itraconazole, whose MIC90 and MIC80 values were 0.14 and 0.50 μg mL-1, respectively. The most potent compound, 45a, exhibited MIC value (8±1 μg mL-1) 16-fold higher than that of itraconazole.