4053-35-4

Basic information

• Product Name: 7-methyl-2-quinolone
• Synonyms: 7-methyl-2-quinolone;7-Methylquinolin-2(1H)-one;Einecs 223-761-2;7-Methyl-1,2-dihydroquinolin-2-one;7-METHYL-1H-QUINOLIN-2-ONE
• CAS NO: 4053-35-4
• Molecular Formula: C₁₀H₉NO
• Molecular Weight: 159.18456
• EINECS: 223-761-2
• Mol File: 4053-35-4.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 346.9°Cat760mmHg
• Flash Point: 202.4°C
• Appearance: /
• Density: 1.15g/cm³
• Vapor Pressure: 5.58E-05mmHg at 25°C
• Refractive Index: 1.584
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 7-methyl-2-quinolone(CAS DataBase Reference)
• NIST Chemistry Reference: 7-methyl-2-quinolone(4053-35-4)
• EPA Substance Registry System: 7-methyl-2-quinolone(4053-35-4)

Safety Data

• Hazardous Substances Data: 4053-35-4(Hazardous Substances Data)

Usage

General Description

7-methyl-2-quinolone is a chemical with the molecular formula C10H9NO. It is a heterocyclic aromatic organic compound that is part of the quinolone family. 7-methyl-2-quinolone is found naturally in a variety of plant species and is also produced industrially for use in the production of pharmaceuticals, dyes, and other organic chemicals. It has been studied for its potential antibacterial, antiviral, and anti-inflammatory properties, and has also been investigated for its role as a signaling molecule in bacteria. The structure and properties of 7-methyl-2-quinolone make it an important chemical in both chemical and biological research.

InChI:InChI=1/C10H9NO/c1-7-2-3-8-4-5-10(12)11-9(8)6-7/h2-6H,1H3,(H,11,12)

Upstream product

• 141-32-2 acrylic acid n-butyl ester 
• 1415586-02-5 C₉H₁₅NO 
• 591-24-2 3-Methylcyclohexanone 
• 108-44-1 1-amino-3-methylbenzene 
• 57830-64-5 3′-methylcinnamanilide 
• 612-60-2 7-methylquinoline 
• 140-88-5 ethyl acrylate 
• 4053-43-4 7-methylquinoline N-oxide 

Downstream Products

• 19352-59-1 3,4-dihydro-7-methyl-2(1H)-quinolinone 

Relevant articles and documents

PRMT5 INHIBITOR COMPOUNDS

A series of PRMT5 inhibitor compounds are described. The compounds are useful as PRMT5 inhibitor compounds and in the treatment of PRMT5 mediated diseases, disorders, and symptoms thereof.

Enantioselective Intermolecular [2 + 2] Photocycloaddition Reactions of 2(1H)-Quinolones Induced by Visible Light Irradiation

In the presence of a chiral thioxanthone catalyst (10 mol %) the title compounds underwent a clean intermolecular [2 + 2] photocycloaddition with electron-deficient olefins at λ = 419 nm. The reactions not only proceeded with excellent regio- and diastereoselectivity but also delivered the respective cyclobutane products with significant enantiomeric excess (up to 95% ee). Key to the success of the reactions is a two-point hydrogen bonding between quinolone and catalyst enabling efficient energy transfer and high enantioface differentiation. Preliminary work indicated that solar irradiation can be used for this process and that the substrate scope can be further expanded to isoquinolones.

2-aminoquinoline-based compounds for potent and selective neuronal nitric oxide synthase inhibition

Various 2-aminoquinoline compounds as can be used, in vivo or in vitro, for selective inhibition of neuronal nitric oxide synthase.